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Laser speckle statistics in ultrasound-modulated optical tomography

Zemp, Roger and Sakadžić, Sava and Kim, Chulhong and Wang, Lihong V. (2007) Laser speckle statistics in ultrasound-modulated optical tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6437. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 64371L. ISBN 9780819465504.

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Ultrasound-Modulated Optical Tomography is a novel biophotonic imaging technique that provides optical contrast with ultrasonic spatial resolution. High temporal coherence laser light and focused ultrasound are transmitted into tissue. Light passing through the acoustic focal volume experiences modulation due to acoustically induced changes in optical index of refraction and optical scatterer displacement. A component of the modulated light may be detected using various detection schemes. One such scheme detects changes in the contrast of optical speckles using a CCD camera. We use statistical optics to derive expressions for the speckle statistics as a function of acoustic parameters. We demonstrate theoretically and experimentally that low acoustic frequencies induce much larger modulation compared with high frequency ultrasound. Theoretically computed values for the speckle contrast are compared with experimental values.

Item Type:Book Section
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2007 Society of Photo-Optical Instrumentation Engineers (SPIE). We gratefully acknowledge funding from the National Institutes of Health, R33 CA 094267.
Funding AgencyGrant Number
NIHR33 CA094267
Subject Keywords:biophotonic imaging, multiply scattered light, optical speckles
Series Name:Proceedings of SPIE
Issue or Number:6437
Record Number:CaltechAUTHORS:20180921-100902998
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Official Citation:Roger Zemp, Roger Zemp, Sava Sakadžić, Sava Sakadžić, Chulhong Kim, Chulhong Kim, Lihong V. Wang, Lihong V. Wang, } "Laser speckle statistics in ultrasound-modulated optical tomography", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64371L (27 February 2007); doi: 10.1117/12.700547;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89840
Deposited By: George Porter
Deposited On:24 Sep 2018 15:33
Last Modified:16 Nov 2021 00:38

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