CaltechAUTHORS
  A Caltech Library Service

Experimental investigation of target and transducer effects on quantitative image reconstruction in photoacoustic tomography

Gamelin, John and Aguirre, Andres and Huang, Fei and Maurudis, Anastasios and Castillo, Diego and Wang, Lihong V. and Zhu, Quing (2007) Experimental investigation of target and transducer effects on quantitative image reconstruction in photoacoustic tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6437. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 64371F. ISBN 9780819465504. https://resolver.caltech.edu/CaltechAUTHORS:20180921-100903185

[img] PDF - Published Version
See Usage Policy.

1MB

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20180921-100903185

Abstract

In principle, absorbed energy profiles can be exactly reconstructed from photoacoustic measurements on a closed surface. Clinical applications, however, involve compromises due to transducer focus, frequency characteristics, and incomplete measurement apertures. These tradeoffs introduce artifacts and errors in reconstructed absorption distributions that affect quantitative interpretations as well as qualitative contrast between features. The quantitative effects of target geometry, limited measurement surfaces, and bandpass transducer frequency response have been investigated using a ring transducer system designed for small animal imaging. The directionality of photoacoustic radiation is shown to increase with target aspect ratio, producing proportionate overestimates of absorption values for two-dimension apertures less than approximately 150 degrees. For all target geometries and orientations, mean absorption values approach the full view values for hemicircular measurement surfaces although the true spatial uniformity is recovered only with the complete surface. The bandpass transducer frequency spectrum produces a peaked amplitude response biased toward spatial features ranging from 1 to 8 times the system resolution. We discuss the implications of these results for design of clinical systems.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.707245DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2007 Society of Photo-Optical Instrumentation Engineers (SPIE). We acknowledge partial support from NIH grants NIH R01 NS46214 and NIH R01EB002136.
Funders:
Funding AgencyGrant Number
NIHR01 NS46214
NIHR01 EB002136
Subject Keywords:Photoacoustic tomography, Limited view tomography, Clinical, Image reconstruction, Quantitative imaging, Array transducers
Series Name:Proceedings of SPIE
Issue or Number:6437
DOI:10.1117/12.707245
Record Number:CaltechAUTHORS:20180921-100903185
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180921-100903185
Official Citation:John Gamelin, John Gamelin, Andres Aguirre, Andres Aguirre, Fei Huang, Fei Huang, Anastasios Maurudis, Anastasios Maurudis, Diego Castillo, Diego Castillo, Lihong V. Wang, Lihong V. Wang, Quing Zhu, Quing Zhu, } "Experimental investigation of target and transducer effects on quantitative image reconstruction in photoacoustic tomography", Proc. SPIE 6437, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 64371F (27 February 2007); doi: 10.1117/12.707245; https://doi.org/10.1117/12.707245
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89842
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:24 Sep 2018 15:19
Last Modified:16 Nov 2021 00:38

Repository Staff Only: item control page