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Ultrasound-modulated optical tomography using four-wave mixing in photorefractive polymers

Zhang, Huiliang and Hemmer, Philip and Wang, Peng and Rokutanda, Shuji and Yamamoto, Michiharu and Wang, Lihong V. (2008) Ultrasound-modulated optical tomography using four-wave mixing in photorefractive polymers. In: Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6856. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 68561S. ISBN 9780819470317. https://resolver.caltech.edu/CaltechAUTHORS:20180921-100903668

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Abstract

Ultrasound-modulated optical tomography uses a well focused ultrasound beam to modulate diffuse light inside soft biological tissues. This modality combines the advantages of ultrasound resolution with optical contrast. However, because of the low ultrasound modulation efficiency, the large background of un-modulated photons gives a low signal-to-noise ratio. Here we report a technique for detection of ultrasound-modulated light using a phase conjugated signal generated by four-wave mixing in a photorefractive polymer. The experimental results demonstrate the potential of this method to detect ultrasound-modulated optical signals in a highly scattering media with an excellent signal-to-noise ratio.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.764987DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2008 Society of Photo-Optical Instrumentation Engineers (SPIE). We appreciate Sava Sakadžić for fruitful scientific discussions. This research was supported by the AFOSR FA9550-04-1-0247, National Institute of Health grant R33 CA 094267 and Nitto Denko Technical Corp.
Funders:
Funding AgencyGrant Number
Air Force Office of Scientific Research (AFOSR)FA9550-04-1-0247
NIHR33 CA 094267
Nitto Denko Technical Corp.UNSPECIFIED
Subject Keywords:Ultrasound-modulated optical tomography, four wave mixing, photorefractive polymer, phase conjugate
Series Name:Proceedings of SPIE
Issue or Number:6856
Record Number:CaltechAUTHORS:20180921-100903668
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180921-100903668
Official Citation:Huiliang Zhang, Huiliang Zhang, Philip Hemmer, Philip Hemmer, Peng Wang, Peng Wang, Shuji Rokutanda, Shuji Rokutanda, Michiharu Yamamoto, Michiharu Yamamoto, Lihong V. Wang, Lihong V. Wang, } "Ultrasound-modulated optical tomography using four-wave mixing in photorefractive polymers", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68561S (28 February 2008); doi: 10.1117/12.764987; https://doi.org/10.1117/12.764987
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89847
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:21 Sep 2018 23:07
Last Modified:03 Oct 2019 20:19

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