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Photoacoustic tomography with novel optical contrast agents based on gold nanocages or nanoparticles containing near-infrared dyes

Yang, Xinmai and Skrabalak, Sara and Stein, Erich and Wu, Bin and Wei, Xunbin and Xia, Younan and Wang, Lihong V. (2008) Photoacoustic tomography with novel optical contrast agents based on gold nanocages or nanoparticles containing near-infrared dyes. In: Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6856. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 68560I. ISBN 9780819470317. http://resolver.caltech.edu/CaltechAUTHORS:20180921-100903985

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Abstract

Poly(ethylene glycol)-coated Au nanocages have been evaluated as a potential near-infrared (NIR) contrast agent for photoacoustic tomography (PAT). Previously, Au nanoshells were found to be an effective NIR contrast agent for PAT; however, Au nanocages, with their more compact sizes (<50 nm compared to >100 nm for Au nanoshells) and larger optical absorption cross-sections, should be better suited for in vivo applications. In this study, we tested Au nanocages as a contrast agent for PAT. The result suggests that Au nanocages are promising contrast agents for our applications. We also present PAT results when novel, dye-containing nanoparticles are used as contrast agents.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.762401DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2008 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored in part by National Institutes of Health Grant Nos. R01 CA106728 and R01 NS46214 (BRP) as well as a Director’s Pioneer Award (5DP1OD000798 to Y. X.) and a grant from NSF (DMR-0451788 to Y. X.). Part of this work was performed at the UW Nanotech User Facility (NTUF), a member of the National Nanotechnology Infrastructure Network (NNIN) funded by NSF.
Funders:
Funding AgencyGrant Number
NIHR01 CA106728
NIHR01 NS46214
NIH5DP1OD000798
NSFDMR-0451788
Subject Keywords:photoacoustic tomography, image reconstruction, nanocages, dye-containing nanoparticles
Record Number:CaltechAUTHORS:20180921-100903985
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180921-100903985
Official Citation:Xinmai Yang, Xinmai Yang, Sara Skrabalak, Sara Skrabalak, Erich Stein, Erich Stein, Bin Wu, Bin Wu, Xunbin Wei, Xunbin Wei, Younan Xia, Younan Xia, Lihong V. Wang, Lihong V. Wang, } "Photoacoustic tomography with novel optical contrast agents based on gold nanocages or nanoparticles containing near-infrared dyes", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68560I (28 February 2008); doi: 10.1117/12.762401; https://doi.org/10.1117/12.762401
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89850
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:21 Sep 2018 23:13
Last Modified:21 Sep 2018 23:13

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