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Deep reflection-mode photoacoustic imaging of internal organs

Song, Kwang Hyun and Wang, Lihong V. (2008) Deep reflection-mode photoacoustic imaging of internal organs. In: Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6856. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 68561W. ISBN 9780819470317.

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A deep reflection-mode photoacoustic imaging system was developed and demonstrated to possess a maximum imaging depth up to 38 mm in chicken breast tissue. Using this system, structures in the thoracic cavity and vasculature in cervical area of rats were clearly imaged. Particularly, part of the heart was imaged. In the thoracic cavity, the right atrium imaged, which is one of deepest, was situated ~7 mm deep. In the cervical area, common carotid artery and jugular vein were imaged, which are appropriate for the study of oxygenation between artery and vein. In the abdominal cavity, the embedded structures of a kidney, spinal cord, and vena cava inferior were also clearly imaged in situ and in vivo. The depth of the vena cava inferior was as deep as ~15 mm in vivo. This study shows the depth capability of the system in animals. This imaging modality can be a useful tool to diagnose the disease of organs by assessing the morphological and functional changes in the blood vessels and the organs.

Item Type:Book Section
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2008 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank Konstantine Maslov for fruitful discussion and assistance. The project sponsored by National Institutes of Health grants R01 CA106728 and R01 NS46214 (BRP).
Funding AgencyGrant Number
NIHR01 CA106728
NIHR01 NS46214
Subject Keywords:Photoacoustic imaging, internal organ, thoracic cavity, cervical, kidney
Series Name:Proceedings of SPIE
Issue or Number:6856
Record Number:CaltechAUTHORS:20180921-100904468
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Official Citation:Kwang Hyun Song, Kwang Hyun Song, Lihong V. Wang, Lihong V. Wang, } "Deep reflection-mode photoacoustic imaging of internal organs", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68561W (28 February 2008); doi: 10.1117/12.761389;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89855
Deposited By: George Porter
Deposited On:21 Sep 2018 23:24
Last Modified:16 Nov 2021 00:38

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