Kothapalli, Sri-Rajasekhar and Sakadžić, Sava and Kim, Chulhong and Wang, Lihong V. (2008) Imaging of optical scattering contrast using ultrasound-modulated optical tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6856. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 68561P. ISBN 9780819470317. https://resolver.caltech.edu/CaltechAUTHORS:20180921-100905041
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Abstract
Using a CCD-based speckle contrast detection scheme of ultrasound-modulated optical tomography (UOT), we show the feasibility of imaging objects having different optical scattering coefficients relative to the surrounding scattering medium. Our results show that the spatial resolution depends on the ultrasound parameters and the image contrast depends on the difference in scattering coefficient between the object and the surrounding medium. Experimental measurements are in agreement with Monte Carlo simulations and analytical calculations. This study complements previous UOT experiments that demonstrated optical absorption contrast. It also demonstrates that UOT complements photoacoustic tomography, which is sensitive to optical absorption contrast.
| Item Type: | Book Section | ||||||
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| Additional Information: | © 2008 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported by the National Institutes of Health grants CA094267 and CA106728. | ||||||
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| Subject Keywords: | speckle contrast, ultrasound-modulated optical tomography, scattering contrast, absorption contrast, optical reduced scattering coefficient, scattering medium, multiple scattering | ||||||
| Series Name: | Proceedings of SPIE | ||||||
| Issue or Number: | 6856 | ||||||
| DOI: | 10.1117/12.761391 | ||||||
| Record Number: | CaltechAUTHORS:20180921-100905041 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180921-100905041 | ||||||
| Official Citation: | Sri-Rajasekhar Kothapalli, Sri-Rajasekhar Kothapalli, Sava Sakadžić, Sava Sakadžić, Chulhong Kim, Chulhong Kim, Lihong V. Wang, Lihong V. Wang, } "Imaging of optical scattering contrast using ultrasound-modulated optical tomography", Proc. SPIE 6856, Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 68561P (11 March 2008); doi: 10.1117/12.761391; https://doi.org/10.1117/12.761391 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 89861 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | George Porter | ||||||
| Deposited On: | 23 Sep 2018 17:16 | ||||||
| Last Modified: | 16 Nov 2021 00:39 |
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