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Epithelial cancer detection by oblique-incidence optical spectroscopy

Garcia-Uribe, Alejandro and Balareddy, Karthik C. and Zou, Jun and Wang, Kenneth K. and Duvic, Madeleine and Wang, Lihong V. (2009) Epithelial cancer detection by oblique-incidence optical spectroscopy. In: Advanced Biomedical and Clinical Diagnostic Systems VII. Proceedings of SPIE. No.7169. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 71690A. ISBN 9780819474155. https://resolver.caltech.edu/CaltechAUTHORS:20180921-100905417

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Abstract

This paper presents a study on non-invasive detection of two common epithelial cancers (skin and esophagus) based on oblique incidence diffuse reflectance spectroscopy (OIDRS). An OIDRS measurement system, which combines fiber optics and MEMS technologies, was developed. In our pilot studies, a total number of 137 cases have been measured in-vivo for skin cancer detection and a total number of 20 biopsy samples have been measured ex-vivo for esophageal cancer detection. To automatically differentiate the cancerous cases from benign ones, a statistical software classification program was also developed. An overall classification accuracy of 90% and 100% has been achieved for skin and esophageal cancer classification, respectively.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.808576DOIArticle
ORCID:
AuthorORCID
Zou, Jun0000-0002-9543-6135
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank the staff of the Skin Cancer and Melanoma Center (UTMDACC) and the Division of Gastroenterology and Hepatology (Mayo Clinic) for their help during the data collection. This project is sponsored by NIH grant R01 CA106728.
Funders:
Funding AgencyGrant Number
NIHR01 CA106728
Subject Keywords:oblique incidence, spectroscopy, MEMS, cancer detection
Series Name:Proceedings of SPIE
Issue or Number:7169
Record Number:CaltechAUTHORS:20180921-100905417
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180921-100905417
Official Citation:Alejandro Garcia-Uribe, Alejandro Garcia-Uribe, Karthik C. Balareddy, Karthik C. Balareddy, Jun Zou, Jun Zou, Kenneth K. Wang, Kenneth K. Wang, Madeleine Duvic, Madeleine Duvic, Lihong V. Wang, Lihong V. Wang, } "Epithelial cancer detection by oblique-incidence optical spectroscopy", Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 71690A (23 February 2009); doi: 10.1117/12.808576; https://doi.org/10.1117/12.808576
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89865
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:23 Sep 2018 17:43
Last Modified:09 Mar 2020 13:19

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