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Monte Carlo simulation of light transport in dark-field confocal photoacoustic microscopy

Xie, Zhixing and Wang, Lihong V. and Zhang, Hao F. (2009) Monte Carlo simulation of light transport in dark-field confocal photoacoustic microscopy. In: Photons Plus Ultrasound: Imaging and Sensing 2009. Proceedings of SPIE. No.7177. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 717717. ISBN 9780819474230.

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A modified MC convolution method for integration extension of MC simulation is developed for finite photon beam with random shape of translational or rotational invariance, which is proven consistent with the conventional convolution extension of MC simulation for normal incident finite beam. The method is applied to analyze the positions of fluence foci and ratios of fluence at the focus and surface which are two key factors in the application of dark-field confocal and some interesting points are presented including: 1) The fluence profile has a saddle-like shape with highest peak in the bright field and low valley near the surface and a second rise in the center of dark field which is defined as the effective optical focus; 2) Besides a little peak near zero inner radius, the ratio of fluences at the focus and surface increases linearly with the inner radius, suggesting the large inner radius more advantageous to image at the effective optical focus; 3) The position of effective optical foci deepens linearly with the increase of the inner radius, suggesting that to get a high quality image of deeper target, a dark-field with larger size is more beneficial. But the position of fluence foci are far away from the foci of geometrical laser beam in high scattering tissue, so aligning the foci of geometrical laser beam and acoustic transducer doesn't guarantee that effective optical focus is accurately overlapping with the acoustic focus. An MC simulation with integration extension presented in this paper maybe helpful to determine where the acoustic focus should be to maximize the SNR in tissue imaging; 4) incident angle makes little difference to ratio of fluences at the focus and surface and an incident angle between 30 and 50 degrees gives the highest fluence at the effective optical focus; 5) the depth of fluence focus is insensitive to the incident angle.

Item Type:Book Section
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was supported in part by The University of Wisconsin-Milwaukee start-up fund and by grant from The Lynde and Harry Bradley Foundation. We also thank Dr. Konstantin Maslov and Dr. Gang Yao for valuable discussions.
Funding AgencyGrant Number
University of Wisconsin-MilwaukeeUNSPECIFIED
Lynde and Harry Bradley FoundationUNSPECIFIED
Subject Keywords:Monte Carlo simulation, photoacoustic microscopy, dark-field illumination
Series Name:Proceedings of SPIE
Issue or Number:7177
Record Number:CaltechAUTHORS:20180921-100905513
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Official Citation:Zhixing Xie, Zhixing Xie, Lihong V. Wang, Lihong V. Wang, Hao F. Zhang, Hao F. Zhang, } "Monte Carlo simulation of light transport in dark-field confocal photoacoustic microscopy", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 717717 (24 February 2009); doi: 10.1117/12.810254;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89866
Deposited By: George Porter
Deposited On:24 Sep 2018 15:43
Last Modified:03 Oct 2019 20:20

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