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Endoscopic photoacoustic microscopy

Yang, Joon-Mo and Maslov, Konstantin and Yang, Hao-Chung and Zhou, Qifa and Wang, Lihong V. (2009) Endoscopic photoacoustic microscopy. In: Photons Plus Ultrasound: Imaging and Sensing 2009. Proceedings of SPIE. No.7177. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 71770N. ISBN 9780819474230.

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We present a concept and system implementation for endoscopic photoacoustic microscopy that enables minimally invasive diagnosis of internal organs. The system incorporates an in-house made single element ultrasonic transducer for photoacoustic signal detection and an optical fiber for light delivery into a tubular probe with a mechanical scanning unit. The implemented probe size for the distal end is 4.2 mm in diameter and 48 mm in length. We evaluated the system's performance by imaging a carbon fiber in clear and turbid media. We also demonstrated its ability to image actual biological tissues and its endoscopic applicability, by imaging abdominal surfaces and a large intestinal tract of a rat ex vivo. This study shows the system's potential for in vivo optical biopsy of tissue abnormalities, such as tumors, developed in internal organs.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was supported by the National Institutes of Health grants R01 NS46214 (BRP), R01 EB000712, R01 EB008085, and U54 CA136398 (Network for Translational Research). L.W. has a financial interest in Endra, Inc., which, however, did not support this work. The authors are grateful to Namiki Precision, Inc. for supporting the micromotor and Hitachi Cable Manchester for supporting the micro-coaxial cable.
Funding AgencyGrant Number
NIHR01 NS46214
NIHR01 EB000712
NIHR01 EB008085
NIHU54 CA136398
Subject Keywords:Endoscopic photoacoustic microscopy, minimally invasive, diagnosis, internal organs, tumors, optical biopsy, scanning mirror, micromotor
Series Name:Proceedings of SPIE
Issue or Number:7177
Record Number:CaltechAUTHORS:20180921-100905786
Persistent URL:
Official Citation:Joon-Mo Yang, Joon-Mo Yang, Konstantin Maslov, Konstantin Maslov, Hao-Chung Yang, Hao-Chung Yang, Qifa Zhou, Qifa Zhou, Lihong V. Wang, Lihong V. Wang, } "Endoscopic photoacoustic microscopy", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71770N (24 February 2009); doi: 10.1117/12.810952;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89869
Deposited By: George Porter
Deposited On:24 Sep 2018 15:53
Last Modified:03 Mar 2020 13:01

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