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Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model

Song, Kwang Hyun and Kim, Chulhong and Cobley, Claire M. and Xia, Younan and Wang, Lihong V. (2009) Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model. In: Photons Plus Ultrasound: Imaging and Sensing 2009. Proceedings of SPIE. No.7177. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 71772L. ISBN 9780819474230. http://resolver.caltech.edu/CaltechAUTHORS:20180921-100906201

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Abstract

Sentinel lymph node biopsy (SLNB) has been widely performed and become the standard procedure for axillary staging in breast cancer patients. In current SLNB, identification of SLNs is prerequisite, and blue dye and/or radioactive colloids are clinically used for mapping. However, these methods are still intraoperative, and especially radioactive colloids based method is ionizing. As a result, SLNB is generally associated with ill side effects. In this study, we have proposed near-infrared Au nanocages as a new tracer for noninvasive and nonionizing photoacoustic (PA) SLN mapping in a rat model as a step toward clinical applications. Au nanocages have great features: biocompatibility, easy surface modification for biomarker, a tunable surface plasmon resonance (SPR) which allows for peak absorption to be optimized for the laser being used, and capsule-type drug delivery. Au nanocage-enhanced photoacoustic imaging has the potential to be adjunctive to current invasive SLNB for preoperative axillary staging in breast cancer patients.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.809676DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2009 Society of Photo-Optical Instrumentation Engineers (SPIE). This research was sponsored in part by grants from National Institutes of Health (R01 EB000712 and R01 NS46214 to L.V.W.). Y.X. thanks the National Institutes of Health for a 2006 Director’s Pioneer Award (5DP1OD000798-04).
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
NIH5DP1OD000798-04
Subject Keywords:photoacoustic, nanocages, sentinel lymph node, mapping
Record Number:CaltechAUTHORS:20180921-100906201
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180921-100906201
Official Citation:Kwang Hyun Song, Kwang Hyun Song, Chulhong Kim, Chulhong Kim, Claire M. Cobley, Claire M. Cobley, Younan Xia, Younan Xia, Lihong V. Wang, Lihong V. Wang, } "Noninvasive photoacoustic sentinel lymph node mapping using Au nanocages as a lymph node tracer in a rat model", Proc. SPIE 7177, Photons Plus Ultrasound: Imaging and Sensing 2009, 71772L (24 February 2009); doi: 10.1117/12.809676; https://doi.org/10.1117/12.809676
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89873
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:24 Sep 2018 16:14
Last Modified:24 Sep 2018 16:14

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