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Pancreatic tumor margin detection by oblique incidence diffuse reflectance spectroscopy

Garcia-Uribe, Alejandro and Chang, Cheng-Chung and Zou, Jun and Banerjee, Bhaskar and Kuczynski, John and Wang, Lihong V. (2011) Pancreatic tumor margin detection by oblique incidence diffuse reflectance spectroscopy. In: Optical Biopsy IX. Proceedings of SPIE. No.7895. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 78950J. ISBN 9780819484321. https://resolver.caltech.edu/CaltechAUTHORS:20180925-095215990

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Abstract

In surgical treatment of pancreatic cancers, the effectiveness of the procedures largely depends on the ability to completely and precisely remove the malignant tumors. We present the ex-vivo use of oblique incidence diffuse reflectance spectroscopy (OIRDS) to detect and differentiate normal from neoplastic tissue. An OIRDS probe has been constructed to provide scattering and absorption information of the pancreatic tissue. To reveal the physiological origin of the difference in these optical signatures, the optical scattering coefficients were extracted along the pancreatic duct with 1-cm spacing. Experimental results show that OIDRS was able to successfully determinate the tumor margins based on the higher optical scattering on malignant tissue.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.875919DOIArticle
ORCID:
AuthorORCID
Zou, Jun0000-0002-9543-6135
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). The authors thank Dr. Andrew Rouse from the University of Arizona Health Sciences Center, for his help during the data collection. This project was sponsored by National Institute of Health grant R01 CA106728.
Funders:
Funding AgencyGrant Number
NIHR01 CA106728
Subject Keywords:diffuse reflectance, scattering, spectroscopy, cancer
Series Name:Proceedings of SPIE
Issue or Number:7895
Record Number:CaltechAUTHORS:20180925-095215990
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180925-095215990
Official Citation:Alejandro Garcia-Uribe, Alejandro Garcia-Uribe, Cheng-Chung Chang, Cheng-Chung Chang, Jun Zou, Jun Zou, Bhaskar Banerjee, Bhaskar Banerjee, John Kuczynski, John Kuczynski, Lihong V. Wang, Lihong V. Wang, } "Pancreatic tumor margin detection by oblique incidence diffuse reflectance spectroscopy", Proc. SPIE 7895, Optical Biopsy IX, 78950J (16 February 2011); doi: 10.1117/12.875919; https://doi.org/10.1117/12.875919
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89909
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Sep 2018 17:39
Last Modified:09 Mar 2020 13:19

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