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In vivo, dual-modality imaging of mouse eyes: optical coherence tomography and photoacoustic microscopy within a single instrument

Rao, Bin and Li, Li and Maslov, Konstantin and Wang, Lihong V. (2010) In vivo, dual-modality imaging of mouse eyes: optical coherence tomography and photoacoustic microscopy within a single instrument. In: Ophthalmic Technologies XX. Proceedings of SPIE. No.7550. Society of Photo-Optical Instrumentation Engineers , Bellingham, WA, Art. No. 75501Q. ISBN 9780819479464. https://resolver.caltech.edu/CaltechAUTHORS:20180925-104554174

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Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) provides superb optical absorption contrast for red blood cells (RBCs), which makes it ideal for in vivo microvasculature imaging. In comparison, optical coherence tomography (OCT), widely used for tissue microstructure imaging, provides high optical scattering contrast. The two contrast mechanisms are highly complementary. In this work, we combined OR-PAM and OCT into a single, dual-modality imaging instrument for in vivo mouse eye imaging. We demonstrated in vivo dual-modality imaging of the anterior segment of mouse eyes with laser pulse energy within the ANSI laser safety standard.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.843041DOIArticle
ORCID:
AuthorORCID
Rao, Bin0000-0001-6494-3110
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 Society of Photo-Optical Instrumentation Engineers (SPIE). The OCT/PAM dual-modality system and mouse ocular anterior segment imaging demonstration were contributed in equal measure by Bin Rao and Li Li. The research was supported by the National Institutes of Health grants R01 EB000712, EB000712A2S1, R01 EB00071207S2, R01 EB008085, R01 CA113453901, U54 CA136398, and 5P60 DK02057933. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHEB000712A2S1
NIHR01 EB00071207S2
NIHR01 EB008085
NIHR01 CA113453901
NIHU54 CA136398
NIH5P60 DK02057933
Subject Keywords:optical coherence tomography, photoacoustic microscopy, anterior segment of eye, iris imaging
Series Name:Proceedings of SPIE
Issue or Number:7550
Record Number:CaltechAUTHORS:20180925-104554174
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180925-104554174
Official Citation:Bin Rao, Bin Rao, Li Li, Li Li, Konstantin Maslov, Konstantin Maslov, Lihong V. Wang, Lihong V. Wang, } "In vivo, dual-modality imaging of mouse eyes: optical coherence tomography and photoacoustic microscopy within a single instrument", Proc. SPIE 7550, Ophthalmic Technologies XX, 75501Q (2 March 2010); doi: 10.1117/12.843041; https://doi.org/10.1117/12.843041
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89912
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Sep 2018 21:55
Last Modified:03 Mar 2020 13:01

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