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Engineering by homologous recombination: exploring sequence and function within a conserved fold

Carbone, Martina N. and Arnold, Frances H. (2007) Engineering by homologous recombination: exploring sequence and function within a conserved fold. Current Opinion in Structural Biology, 17 (4). pp. 454-459. ISSN 0959-440X. doi:10.1016/j.sbi.2007.08.005. https://resolver.caltech.edu/CaltechAUTHORS:20180925-112232037

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Abstract

In nature similar protein folds accommodate distant sequences and support diverse functions. This observation coupled with the recognition that proteins can tolerate many homologous substitutions inspires protein engineers to use recombination to search for new functions within sequences encoding structurally related molecules. These searches have led to proteins with novel activities, diversified specificities and greater stabilities. Computational methods that exploit structural and evolutionary information are being used to design highly mutated yet still natively folded chimeric proteins and protein libraries.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.sbi.2007.08.005DOIArticle
ORCID:
AuthorORCID
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 2007 Elsevier Ltd. Available online 19 September 2007. This work is supported by the National Institutes of Health (R01 GM068664-0) and a National Science Foundation Predoctoral Fellowship (to MC).
Funders:
Funding AgencyGrant Number
NIHR01 GM068664-0
NSF Predoctoral FellowshipUNSPECIFIED
Issue or Number:4
DOI:10.1016/j.sbi.2007.08.005
Record Number:CaltechAUTHORS:20180925-112232037
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180925-112232037
Official Citation:Martina N Carbone, Frances H Arnold, Engineering by homologous recombination: exploring sequence and function within a conserved fold, Current Opinion in Structural Biology, Volume 17, Issue 4, 2007, Pages 454-459, ISSN 0959-440X, https://doi.org/10.1016/j.sbi.2007.08.005. (http://www.sciencedirect.com/science/article/pii/S0959440X07001121)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89916
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:25 Sep 2018 21:54
Last Modified:16 Nov 2021 00:39

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