Maslov, Konstantin and Wang, Lihong V. (2005) High-resolution photoacoustic vascular imaging in vivo using a large-aperture acoustic lens. In: Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.5697. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 7-14. ISBN 9780819456717. https://resolver.caltech.edu/CaltechAUTHORS:20180926-074136300
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Abstract
Reflection-mode photoacoustic microscopy with dark-field laser pulse illumination and high frequency ultrasonic detection is used to non-invasively image blood vessels in the skin in vivo. Dark-field illumination minimizes the interference caused by strong photoacoustic signals from superficial structures. A high numerical-aperture acoustic lens provides high lateral resolution, 45-120 micrometers in this system while a broadband ultrasonic detection system provides high axial resolution, estimated to be ~15-20 micrometers. The optical illumination and ultrasonic detection are in a coaxial confocal configuration for optimal image quality. The system is capable of imaging optical-absorption contrast at up to 3 mm depth in biological tissue.
| Item Type: | Book Section | ||||||
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| Additional Information: | © 2005 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored by the National Institutes of Health grants R01 EB000712 and R01 NS46214. | ||||||
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| Subject Keywords: | Medical and biological imaging, Photoacoustic imaging, Scanning microscopy | ||||||
| Series Name: | Proceedings of SPIE | ||||||
| Issue or Number: | 5697 | ||||||
| DOI: | 10.1117/12.590558 | ||||||
| Record Number: | CaltechAUTHORS:20180926-074136300 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180926-074136300 | ||||||
| Official Citation: | Konstantin Maslov, Konstantin Maslov, Lihong V. Wang, Lihong V. Wang, } "High-resolution photoacoustic vascular imaging in vivo using a large-aperture acoustic lens", Proc. SPIE 5697, Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, (25 April 2005); doi: 10.1117/12.590558; https://doi.org/10.1117/12.590558 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 89940 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 26 Sep 2018 18:25 | ||||||
| Last Modified: | 16 Nov 2021 00:39 |
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