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High-resolution photoacoustic vascular imaging in vivo using a large-aperture acoustic lens

Maslov, Konstantin and Wang, Lihong V. (2005) High-resolution photoacoustic vascular imaging in vivo using a large-aperture acoustic lens. In: Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.5697. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 7-14. ISBN 9780819456717. https://resolver.caltech.edu/CaltechAUTHORS:20180926-074136300

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Abstract

Reflection-mode photoacoustic microscopy with dark-field laser pulse illumination and high frequency ultrasonic detection is used to non-invasively image blood vessels in the skin in vivo. Dark-field illumination minimizes the interference caused by strong photoacoustic signals from superficial structures. A high numerical-aperture acoustic lens provides high lateral resolution, 45-120 micrometers in this system while a broadband ultrasonic detection system provides high axial resolution, estimated to be ~15-20 micrometers. The optical illumination and ultrasonic detection are in a coaxial confocal configuration for optimal image quality. The system is capable of imaging optical-absorption contrast at up to 3 mm depth in biological tissue.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.590558DOIArticle
ORCID:
AuthorORCID
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2005 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored by the National Institutes of Health grants R01 EB000712 and R01 NS46214.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
Subject Keywords:Medical and biological imaging, Photoacoustic imaging, Scanning microscopy
Series Name:Proceedings of SPIE
Issue or Number:5697
DOI:10.1117/12.590558
Record Number:CaltechAUTHORS:20180926-074136300
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180926-074136300
Official Citation:Konstantin Maslov, Konstantin Maslov, Lihong V. Wang, Lihong V. Wang, } "High-resolution photoacoustic vascular imaging in vivo using a large-aperture acoustic lens", Proc. SPIE 5697, Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, (25 April 2005); doi: 10.1117/12.590558; https://doi.org/10.1117/12.590558
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89940
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Sep 2018 18:25
Last Modified:16 Nov 2021 00:39

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