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Breast cancer imaging by microwave-induced thermoacoustic tomography

Xu, Minghua and Ku, Geng and Jin, Xing and Wang, Lihong V. (2005) Breast cancer imaging by microwave-induced thermoacoustic tomography. In: Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.5697. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 45-48. ISBN 9780819456717. http://resolver.caltech.edu/CaltechAUTHORS:20180926-074540100

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Abstract

We report a preliminary study of breast cancer imaging by microwave-induced thermoacoustic tomography. In this study, we built a prototype of breast cancer imager based on a circular scan mode. A 3-GHz 0.3~0.5-μs microwave is used as the excitation energy source. A 2.25-MHz ultrasound transducer scans the thermoacoustic signals. All the measured data is transferred to a personal computer for imaging based on our proposed back-projection reconstruction algorithms. We quantified the line spread function of the imaging system. It shows the spatial resolution of our experimental system reaches 0.5 mm. After phantom experiments demonstrated the principle of this technique, we moved the imaging system to the University of Texas MD Anderson Cancer Center to image the excised breast cancer specimens. After the surgery performed by the physicians at the Cancer Center, the excised breast specimen was placed in a plastic cylindrical container with a diameter of 10 cm; and it was then imaged by three imaging modalities: radiograph, ultrasound and thermoacoustic imaging. Four excised breast specimens have been tested. The tumor regions have been clearly located. This preliminary study demonstrated the potential of microwave-induced thermoacoustic tomography for applications in breast cancer imaging.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.589128DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2005 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored in part by the U.S. Army Medical Research and Materiel Command Grant No. DAMD17-00-1-0455, the National Institutes of Health Grants No. R01 EB000712 and No. R01 NS46214, and Texas Higher Education Coordinating Board Grant No. ARP 000512-0063-2001.
Funders:
Funding AgencyGrant Number
Army Medical Research and Materiel CommandDAMD17-00-1-0455
NIHR01 EB000712
NIHR01 NS46214
Texas Higher Education Coordinating BoardARP 000512-0063-2001
Subject Keywords:Breast cancer, imaging, microwave, thermoacoustic tomography
Record Number:CaltechAUTHORS:20180926-074540100
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180926-074540100
Official Citation:Minghua Xu, Minghua Xu, Geng Ku, Geng Ku, Xing Jin, Xing Jin, Lihong V. Wang, Lihong V. Wang, Bruno D. Fornage, Bruno D. Fornage, Kelly K. Hunt, Kelly K. Hunt, } "Breast cancer imaging by microwave-induced thermoacoustic tomography", Proc. SPIE 5697, Photons Plus Ultrasound: Imaging and Sensing 2005: The Sixth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, (25 April 2005); doi: 10.1117/12.589128; https://doi.org/10.1117/12.589128
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89941
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Sep 2018 18:24
Last Modified:26 Sep 2018 18:24

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