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Analysis of physiological parameters in skin tumors by a scaleable Monte Carlo simulation

Garcia-Uribe, Alejandro and Wang, Lihong V. (2005) Analysis of physiological parameters in skin tumors by a scaleable Monte Carlo simulation. In: Optical Interactions with Tissue and Cells XVI. Proceedings of SPIE. No.5695. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 122-127. ISBN 9780819456694. https://resolver.caltech.edu/CaltechAUTHORS:20180926-081507738

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Abstract

This paper presents a study of the use of a single scaleable Monte Carlo simulation to estimate the physiological parameters of skin lesions from data collected in vivo using spectroscopic oblique-incidence reflectometry. Spatio-spectral data from 101 cases are separated into two groups based on their melanocytic conditions. Group-1 consists of (a) cancerous basal cell carcinomas and squamous cell carcinomas and (b) benign actinic keratoses and seborrheic keratoses. Group-2 consists of (a) dysplastic nevi and (b) benign common nevi. Several physiological parameters are estimated, such as the size distribution of the optical scatterers, the relative index of refraction of the scatterers, the total volume concentration of the scatterers, the concentration of the total hemoglobin and the oxygen saturation, and the relative changes related to the values calculated from the neighboring healthy tissues. The most significant features are then combined into one feature. The results show that for both groups the combined feature is significantly different for the benign and cancerous cases than for the dysplastic cases. The ROC area was 0.9 and 0.86 for group-1 and group-2, respectively.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.590308DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2005 Society of Photo-optical Instrumentation Engineers (SPIE). This project is sponsored by NIH grant R01 CA106728.
Funders:
Funding AgencyGrant Number
NIHR01 CA106728
Subject Keywords:Oblique incidence reflectometry, Spectroscopy, Monte Carlo, Skin Cancer, Lesion classification, Physiological origin
Series Name:Proceedings of SPIE
Issue or Number:5695
DOI:10.1117/12.590308
Record Number:CaltechAUTHORS:20180926-081507738
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180926-081507738
Official Citation:Alejandro Garcia-Uribe, Alejandro Garcia-Uribe, Lihong V. Wang, Lihong V. Wang, } "Analysis of physiological parameters in skin tumors by a scaleable Monte Carlo simulation", Proc. SPIE 5695, Optical Interactions with Tissue and Cells XVI, (15 April 2005); doi: 10.1117/12.590308; https://doi.org/10.1117/12.590308
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89945
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Sep 2018 18:20
Last Modified:16 Nov 2021 00:39

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