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In vivo tomographic imaging based on bioluminescence

Cong, Wenxiang and Durairaj, Kumar and Kang, Yubin and Sinn, Patrick and Nixon, Earl and Mienel, John, Jr. and Suter, Melissa and Wang, Lihong V. and McLennan, Geoffrey and Hoffman, Eric A. and Wang, Ge (2004) In vivo tomographic imaging based on bioluminescence. In: Developments in X-Ray Tomography IV. Proceedings of SPIE. No.5535. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 212-219. ISBN 9780819454737. https://resolver.caltech.edu/CaltechAUTHORS:20180926-100531566

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Abstract

The most important task for bioluminescence imaging is to identify the emission source from the captured bioluminescent signal on the surface of a small tested animal. Quantitative information on the source location, geometry and intensity serves for in-vivo monitoring of infectious diseases, tumor growth, metastases in the small animal. In this paper, we present a point-spread function-based method for reconstructing the internal bioluminescent source from the surface light output flux signal. The method is evaluated for sensing the internal emission sources in nylon phantoms and within a live mouse. The surface bioluminescent signal is taken with a highly sensitive CCD camera. The results show the feasibility and efficiency of the proposed point-spread function-based method.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.560522DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2004 Society of Photo-optical Instrumentation Engineers (SPIE). This work is partially supported by NIH/NIBIB grants (EB001685).
Funders:
Funding AgencyGrant Number
NIHEB001685
Subject Keywords:Bioluminescence tomography, CT/micro-CT, molecular imaging, point-spread function (PSF)
Series Name:Proceedings of SPIE
Issue or Number:5535
Record Number:CaltechAUTHORS:20180926-100531566
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180926-100531566
Official Citation:Wenxiang Cong, Wenxiang Cong, Durairaj Kumar, Durairaj Kumar, Yubin Kang, Yubin Kang, Patrick Sinn, Patrick Sinn, Earl Nixon, Earl Nixon, John Mienel, John Mienel, Melissa J. Suter, Melissa J. Suter, Lihong V. Wang, Lihong V. Wang, Geoffrey McLennan, Geoffrey McLennan, Eric A. Hoffman, Eric A. Hoffman, Ge Wang, Ge Wang, } "In vivo tomographic imaging based on bioluminescence", Proc. SPIE 5535, Developments in X-Ray Tomography IV, (26 October 2004); doi: 10.1117/12.560522;https://doi.org/10.1117/12.560522
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89954
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Sep 2018 18:17
Last Modified:03 Oct 2019 20:20

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