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Genetics in non-genetic model systems

Lois, Carlos and Groves, James O. (2012) Genetics in non-genetic model systems. Current Opinion in Neurobiology, 22 (1). pp. 79-85. ISSN 0959-4388. PMCID PMC3320209. doi:10.1016/j.conb.2011.11.002.

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The past few decades have seen the field of genetic engineering evolve at a rapid pace, with neuroscientists now equipped with a wide range of tools for the manipulation of an animal's genome in order to study brain function. However, the number of species to which these technologies have been applied, namely the fruit fly, C. elegans, zebrafish and mouse, remains relatively few. This review will discuss the variety of approaches to genetic modification that have been developed in such traditional ‘genetic systems’, and highlight the progress that has been made to translate these technologies to alternative species such as rats, monkeys and birds, where certain neurobiological questions may be better studied.

Item Type:Article
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URLURL TypeDescription CentralArticle
Lois, Carlos0000-0002-7305-2317
Additional Information:© 2011 Elsevier Ltd. Available online 24 November 2011.
Issue or Number:1
PubMed Central ID:PMC3320209
Record Number:CaltechAUTHORS:20180926-140008893
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Official Citation:Carlos Lois, James O Groves, Genetics in non-genetic model systems, Current Opinion in Neurobiology, Volume 22, Issue 1, 2012, Pages 79-85, ISSN 0959-4388, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89968
Deposited By: Tony Diaz
Deposited On:26 Sep 2018 21:05
Last Modified:16 Nov 2021 00:39

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