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Retroviruses as tools to study the immune system

Lois, Carlos and Refaeli, Yosef and Qin, Xiao-Feng and Van Parijs, Luk (2001) Retroviruses as tools to study the immune system. Current Opinion in Immunology, 13 (4). pp. 496-504. ISSN 0952-7915. https://resolver.caltech.edu/CaltechAUTHORS:20180926-140405562

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Abstract

Retrovirus-based vectors provide an efficient means to introduce and express genes in cells of the immune system and have become a popular tool to study immune function. They are easy to manipulate and provide stable, long-term gene expression because they integrate into the genome. Current retroviral vectors do have limitations that affect their usefulness in certain applications. However, recent advances suggest a number of ways in which these vectors might be improved to extend their utility in immunological research.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/S0952-7915(00)00247-8DOIArticle
ORCID:
AuthorORCID
Lois, Carlos0000-0002-7305-2317
Additional Information:© 2001 Elsevier Science Ltd. Available online 3 August 2001. The authors wish to thank David Baltimore (California Institute of Technology), Martin Scott (Biogen Inc.) and Warren Pear (University of Pennsylvania) for their helpful comments on the manuscript. LVP is supported by a Career Development Award from the Juvenile Diabetes Research Foundation and an award from the David Koch Research Fund; CL is funded by the Christopher Reeves Paralysis Foundation, YR is a Merck Fellow of the Life Sciences Foundation and X-FQ is funded by a Damon Runyon-Walter Winchell Fellowship (DRG 1568).
Funders:
Funding AgencyGrant Number
Juvenile Diabetes Research FoundationUNSPECIFIED
David Koch Research FundUNSPECIFIED
Christopher Reeves Paralysis FoundationUNSPECIFIED
Life Sciences FoundationUNSPECIFIED
Damon Runyon-Walter Winchell Cancer FundDRG 1568
Subject Keywords:retroviral vectors; gene transfer; immune cells; stem cells; promoters; regulated gene expression; bicistronic vectors
Issue or Number:4
Record Number:CaltechAUTHORS:20180926-140405562
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180926-140405562
Official Citation:Carlos Lois, Yosef Refaeli, Xiao-Feng Qin, Luk Van Parijs, Retroviruses as tools to study the immune system, Current Opinion in Immunology, Volume 13, Issue 4, 2001, Pages 496-504, ISSN 0952-7915, https://doi.org/10.1016/S0952-7915(00)00247-8. (http://www.sciencedirect.com/science/article/pii/S0952791500002478)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89969
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Sep 2018 21:48
Last Modified:03 Oct 2019 20:21

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