Lois, Carlos and Refaeli, Yosef and Qin, Xiao-Feng and Van Parijs, Luk (2001) Retroviruses as tools to study the immune system. Current Opinion in Immunology, 13 (4). pp. 496-504. ISSN 0952-7915. doi:10.1016/S0952-7915(00)00247-8. https://resolver.caltech.edu/CaltechAUTHORS:20180926-140405562
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Abstract
Retrovirus-based vectors provide an efficient means to introduce and express genes in cells of the immune system and have become a popular tool to study immune function. They are easy to manipulate and provide stable, long-term gene expression because they integrate into the genome. Current retroviral vectors do have limitations that affect their usefulness in certain applications. However, recent advances suggest a number of ways in which these vectors might be improved to extend their utility in immunological research.
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| Additional Information: | © 2001 Elsevier Science Ltd. Available online 3 August 2001. The authors wish to thank David Baltimore (California Institute of Technology), Martin Scott (Biogen Inc.) and Warren Pear (University of Pennsylvania) for their helpful comments on the manuscript. LVP is supported by a Career Development Award from the Juvenile Diabetes Research Foundation and an award from the David Koch Research Fund; CL is funded by the Christopher Reeves Paralysis Foundation, YR is a Merck Fellow of the Life Sciences Foundation and X-FQ is funded by a Damon Runyon-Walter Winchell Fellowship (DRG 1568). | ||||||||||||
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| Subject Keywords: | retroviral vectors; gene transfer; immune cells; stem cells; promoters; regulated gene expression; bicistronic vectors | ||||||||||||
| Issue or Number: | 4 | ||||||||||||
| DOI: | 10.1016/S0952-7915(00)00247-8 | ||||||||||||
| Record Number: | CaltechAUTHORS:20180926-140405562 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20180926-140405562 | ||||||||||||
| Official Citation: | Carlos Lois, Yosef Refaeli, Xiao-Feng Qin, Luk Van Parijs, Retroviruses as tools to study the immune system, Current Opinion in Immunology, Volume 13, Issue 4, 2001, Pages 496-504, ISSN 0952-7915, https://doi.org/10.1016/S0952-7915(00)00247-8. (http://www.sciencedirect.com/science/article/pii/S0952791500002478) | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 89969 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | Tony Diaz | ||||||||||||
| Deposited On: | 26 Sep 2018 21:48 | ||||||||||||
| Last Modified: | 16 Nov 2021 00:39 |
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