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Chain Migration of Neuronal Precursors

Lois, Carlos and Garcia-Verdugo, José-Manuel and Alvarez-Buylla, Arturo (1996) Chain Migration of Neuronal Precursors. Science, 271 (5251). pp. 978-981. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20180926-142441162

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Abstract

In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1126/science.271.5251.978DOIArticle
ORCID:
AuthorORCID
Lois, Carlos0000-0002-7305-2317
Garcia-Verdugo, José-Manuel0000-0001-9872-6499
Alvarez-Buylla, Arturo0000-0003-4426-8925
Additional Information:© 1996 American Association for the Advancement of Science. Received 13 September 1995; accepted 21 November 1995. We thank F. Nottebohm, E. Font, and F. Doetsch for critically reading the manuscript, G. Rougon for antibodies to PSA-N-CAM, and E. Sphicas for help with postembedding immunocytochemistry. Supported by NIH grants NS28478 and HD32116 to A.A.B, and DGICYT PB91-0643 (Spain) to J.-M.G.-V. C.L. is a recipient of a La Caixa Foundation graduate program fellowship.
Funders:
Funding AgencyGrant Number
NIHNS28478
NIHHD32116
Departmento Governmental de Investigaciónes Cientificas y TécnológicasPB91-0643
La Caixa FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20180926-142441162
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180926-142441162
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89972
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Sep 2018 21:44
Last Modified:03 Oct 2018 21:43

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