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Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications

Wu, Xiang and Zhang, Yuanwei and Takle, Kendra and Bilsel, Osman and Li, Zhanjun and Lee, Hyungseok and Zhang, Zijiao and Li, Dongsheng and Fan, Wei and Duan, Chunying and Chan, Emory M. and Lois, Carlos and Xiang, Yang and Han, Gang (2016) Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. ACS Nano, 10 (1). pp. 1060-1066. ISSN 1936-0851. PMCID PMC4913696. http://resolver.caltech.edu/CaltechAUTHORS:20180926-144824986

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Abstract

Near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. Here, we achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb^(3+)) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1021/acsnano.5b06383DOIArticle
https://pubs.acs.org/doi/suppl/10.1021/acsnano.5b06383PublisherSupporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913696PubMed CentralArticle
ORCID:
AuthorORCID
Lois, Carlos0000-0002-7305-2317
Additional Information:© 2016 American Chemical Society. Received: October 10, 2015; Accepted: January 6, 2016; Published: January 6, 2016. This research was supported by the China Scholarship Council (CSC) to X.W., a Worcester Foundation Mel Cutler Award, National Institutes of Health R01MH103133 to G.H, C.L., and Y.X., Human Frontier Science Program RGY-0090/2014 to G.H. and Y.X. Quantum yield work (E.M.C.) at the Molecular Foundry was supported by the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. D.L. is supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences Early Career Research Program, under Award No. 67037. We also thank Dr. Shaul Aloni’s help in TEM measurements. Author Contributions: X. Wu, Y. Zhang, and K. Takle contributed equally to this work. The authors declare no competing financial interest.
Funders:
Funding AgencyGrant Number
China Scholarship CouncilUNSPECIFIED
Worcester FoundationUNSPECIFIED
NIHR01MH103133
Human Frontier Science ProgramRGY-0090/2014
Department of Energy (DOE)DE-AC02-05CH11231
Department of Energy (DOE)67037
Subject Keywords:bioimaging, core/active shell structure, dye-sensitizing, near-infrared, optogenetics, upconversion nanoparticles
PubMed Central ID:PMC4913696
Record Number:CaltechAUTHORS:20180926-144824986
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20180926-144824986
Official Citation:Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. Xiang Wu, Yuanwei Zhang, Kendra Takle, Osman Bilsel, Zhanjun Li, Hyungseok Lee, Zijiao Zhang, Dongsheng Li, Wei Fan, Chunying Duan, Emory M. Chan, Carlos Lois, Yang Xiang, and Gang Han. ACS Nano 2016 10 (1), 1060-1066. DOI: 10.1021/acsnano.5b06383
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89976
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Sep 2018 22:20
Last Modified:26 Sep 2018 22:20

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