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Neuronal stem cells in the brain of adult vertebrates

Alvarez-Buylla, Arturo and Lois, Carlos (1995) Neuronal stem cells in the brain of adult vertebrates. Stem Cells, 13 (3). pp. 263-272. ISSN 1549-4918. doi:10.1002/stem.5530130307.

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It is generally assumed that neurogenesis in the central nervous system ceases before or soon after birth. In the last three decades, however, several studies have reported that new neurons continue to be added into the brain of adult fish, frogs, reptiles, birds and mammals. The precursor cells that give rise to the neurons generated in adulthood are generally located in the walls of the brain ventricles. From these proliferative regions, neuronal precursors migrate toward their final targets where they differentiate; they often traverse long distances through complex brain parenchyma. The identity of the neuronal precursors in the brains of adult animals is still unknown. Experiments in adult birds suggest that proliferating radial cells may be the neuronal precursors. In adult mice, cells present in the sub‐ventricular zone can generate neurons in vivo and in vitro. These neuronal precursors can be induced to proliferate in vitro when exposed to growth factors and retain their potential to differentiate into neurons and glia. Whether these putative neural stem cells can differentiate into multiple neuronal types remains to be determined. The neuronal precursors of the adult brain could be used as a source of cells for neuronal transplantation. In addition, these cells could be manipulated in vivo or in vitro to introduce genes into the brain. Adult neurogenesis offers new experimental opportunities to study neuronal birth, migration and differentiation and for the treatment of neurological diseases.

Item Type:Article
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URLURL TypeDescription
Alvarez-Buylla, Arturo0000-0003-4426-8925
Lois, Carlos0000-0002-7305-2317
Additional Information:© 1995 AlphaMed Press. Received January 20, 1995; accepted for publication January 20, 1995. This work was supported by NIH grant HD32116 and a Sinsheimer award.
Funding AgencyGrant Number
Sinsheimer AwardUNSPECIFIED
Subject Keywords:Neurogenesis; Central nervous system; Neural stem cells; Postnatal; Neuronal migration
Issue or Number:3
Record Number:CaltechAUTHORS:20180926-154538888
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Official Citation:Alvarez‐Buylla, A. and Lois, C. (1995), Neuronal stem cells in the brain of adult vertebrates. STEM CELLS, 13: 263-272. doi:10.1002/stem.5530130307
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89979
Deposited By: Tony Diaz
Deposited On:26 Sep 2018 23:29
Last Modified:16 Nov 2021 00:39

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