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Genetic Strategy to Prevent Influenza Virus Infections in Animals

Chen, Jianzhu and Chen, Steve C.-Y. and Stern, Patrick and Scott, Benjamin B. and Lois, Carlos (2008) Genetic Strategy to Prevent Influenza Virus Infections in Animals. Journal of Infectious Diseases, 197 (S1). S25-S28. ISSN 0022-1899. PMCID PMC2694447. doi:10.1086/524987.

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The natural reservoirs of influenza viruses are aquatic birds. After adaptation, avian viruses can acquire the ability to infect humans and cause severe disease. Because domestic poultry serves as a key link between the natural reservoir of influenza viruses and epidemics and pandemics in human populations, an effective measure to control influenza would be to eliminate or reduce influenza virus infection in domestic poultry. The development and distribution of influenza-resistant poultry represents a proactive strategy for controlling the origin of influenza epidemics and pandemics in both poultry and human populations. Recent developments in RNA interference and transgenesis in birds should facilitate the development of influenza-resistant poultry.

Item Type:Article
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URLURL TypeDescription CentralArticle
Lois, Carlos0000-0002-7305-2317
Additional Information:© 2008 by the Infectious Diseases Society of America. Potential conflicts of interest: none reported. Financial support: National Institutes of Health (grants AI56267, CA119349, and CA112967). Supplement sponsorship is detailed in the Acknowledgments. We thank Herman N. Eisen for his discussion and critical reading of the manuscript. The Harvard University Asian Flus and Avian Influenza Workshop was hosted by the Harvard University Department of Anthropology, Harvard School of Public Health, and Harvard Asia Center and was supported by the National Science Foundation, Harvard Asia Center, and the Michael Crichton Fund. Supplement sponsorship. This article was published as part of a supplement entitled “Avian and Pandemic Influenza: A Biosocial Approach,” sponsored by the National Science Foundation, Harvard Asia Center, and the Michael Crichton Fund.
Funding AgencyGrant Number
Harvard Asia CenterUNSPECIFIED
Michael Crichton FundUNSPECIFIED
Subject Keywords:influenza gene transfer techniques aves orthomyxoviridae infection genetics fowls, domestic poultry meat viruses epidemics rna interference pandemic
Issue or Number:S1
PubMed Central ID:PMC2694447
Record Number:CaltechAUTHORS:20180926-155832879
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Official Citation:Jianzhu Chen, Steve C.-Y. Chen, Patrick Stern, Benjamin B. Scott, Carlos Lois; Genetic Strategy to Prevent Influenza Virus Infections in Animals, The Journal of Infectious Diseases, Volume 197, Issue Supplement_1, 15 February 2008, Pages S25–S28,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89980
Deposited By: Tony Diaz
Deposited On:26 Sep 2018 23:28
Last Modified:16 Nov 2021 00:39

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