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Wandering Neuronal Migration in the Postnatal Vertebrate Forebrain

Scott, Benjamin B. and Gardner, Timothy and Ji, Ni and Fee, Michale S. and Lois, Carlos (2012) Wandering Neuronal Migration in the Postnatal Vertebrate Forebrain. Journal of Neuroscience, 32 (4). pp. 1436-1446. ISSN 0270-6474. https://resolver.caltech.edu/CaltechAUTHORS:20180926-160608266

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Abstract

Most non-mammalian vertebrate species add new neurons to existing brain circuits throughout life, a process thought to be essential for tissue maintenance, repair, and learning. How these new neurons migrate through the mature brain and which cues trigger their integration within a functioning circuit is not known. To address these questions, we used two-photon microscopy to image the addition of genetically labeled newly generated neurons into the brain of juvenile zebra finches. Time-lapse in vivo imaging revealed that the majority of migratory new neurons exhibited a multipolar morphology and moved in a nonlinear manner for hundreds of micrometers. Young neurons did not use radial glia or blood vessels as a migratory scaffold; instead, cells extended several motile processes in different directions and moved by somal translocation along an existing process. Neurons were observed migrating for ∼2 weeks after labeling injection. New neurons were observed to integrate in close proximity to the soma of mature neurons, a behavior that may explain the emergence of clusters of neuronal cell bodies in the adult songbird brain. These results provide direct, in vivo evidence for a wandering form of neuronal migration involved in the addition of new neurons in the postnatal brain.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/JNEUROSCI.2145-11.2012DOIArticle
https://doi.org/10.1523/JNEUROSCI.2172-12.2012DOIErratum
ORCID:
AuthorORCID
Lois, Carlos0000-0002-7305-2317
Additional Information:© 2012 the authors. For the first six months after publication SfN’s license will be exclusive. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received April 29, 2011; revised Nov. 8, 2011; accepted Nov. 19, 2011. This work was supported by a grant from the Ellison Foundation (C.L.). We thank S. Turaga and A. Andalman for help with data analysis and T. Davidson and N. Denisenko for their comments on this manuscript. Author contributions: B.B.S., T.G., and C.L. designed research; B.B.S., T.G., N.J., and C.L. performed research; B.B.S., T.G., M.S.F., and C.L. contributed unpublished reagents/analytic tools; B.B.S., T.G., and C.L. analyzed data; B.B.S. and C.L. wrote the paper.
Funders:
Funding AgencyGrant Number
Ellison Medical FoundationUNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20180926-160608266
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180926-160608266
Official Citation:Wandering Neuronal Migration in the Postnatal Vertebrate Forebrain. Benjamin B. Scott, Timothy Gardner, Ni Ji, Michale S. Fee, Carlos Lois. Journal of Neuroscience 25 January 2012, 32 (4) 1436-1446; DOI: 10.1523/JNEUROSCI.2145-11.2012
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:89981
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Sep 2018 23:27
Last Modified:03 Oct 2019 20:21

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