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Hard Limits And Performance Tradeoffs In A Class Of Sequestration Feedback Systems

Olsman, Noah and Baetica, Ania-Ariadna and Xiao, Fangzhou and Leong, Yoke Peng and Murray, Richard and Doyle, John (2017) Hard Limits And Performance Tradeoffs In A Class Of Sequestration Feedback Systems. . (Unpublished)

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Feedback regulation is pervasive in biology at both the organismal and cellular level. In this article, we explore the properties of a particular biomolecular feedback mechanism implemented using the sequestration binding of two molecules. Our work develops an analytic framework for understanding the hard limits, performance tradeoffs, and architectural properties of this simple model of biological feedback control. Using tools from control theory, we show that there are simple parametric relationships that determine both the stability and the performance of these systems in terms of speed, robustness, steady-state error, and leakiness. These findings yield a holistic understanding of the behavior of sequestration feedback and contribute to a more general theory of biological control systems.

Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription Paper
Olsman, Noah0000-0002-4351-3880
Baetica, Ania-Ariadna0000-0003-0421-8181
Xiao, Fangzhou0000-0002-5001-5644
Leong, Yoke Peng0000-0001-8560-8856
Murray, Richard0000-0002-5785-7481
Doyle, John0000-0002-1828-2486
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license. The authors would like to thank Reed McCardell for providing insight into the synthetic growth circuit, and Hana El-Samad for providing feedback on the manuscript. The project was sponsored by the Defense Advanced Research Projects Agency (Agreement HR0011-17-2-0008). The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. Author Contributions: Conceptualization and Methodology, NO, AAB, FX, YPL, JCD, and RMM; Formal Analysis, NO, AAB, FX, and YPL; Software, NO, AAB, and YPL; Writing, NO, AAB, and FX; Supervision and Funding, JCD and RMM. The authors declare no competing interests.
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)HR0011-17-2-0008
Record Number:CaltechAUTHORS:20180927-114225422
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90015
Deposited By: George Porter
Deposited On:27 Sep 2018 20:21
Last Modified:16 Nov 2021 00:40

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