Olsman, Noah and Baetica, Ania-Ariadna and Xiao, Fangzhou and Leong, Yoke Peng and Murray, Richard and Doyle, John (2017) Hard Limits And Performance Tradeoffs In A Class Of Sequestration Feedback Systems. . (Unpublished) http://resolver.caltech.edu/CaltechAUTHORS:20180927-114225422
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Abstract
Feedback regulation is pervasive in biology at both the organismal and cellular level. In this article, we explore the properties of a particular biomolecular feedback mechanism implemented using the sequestration binding of two molecules. Our work develops an analytic framework for understanding the hard limits, performance tradeoffs, and architectural properties of this simple model of biological feedback control. Using tools from control theory, we show that there are simple parametric relationships that determine both the stability and the performance of these systems in terms of speed, robustness, steady-state error, and leakiness. These findings yield a holistic understanding of the behavior of sequestration feedback and contribute to a more general theory of biological control systems.
| Item Type: | Report or Paper (Discussion Paper) | ||||||||||||||
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| Additional Information: | The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license. The authors would like to thank Reed McCardell for providing insight into the synthetic growth circuit, and Hana El-Samad for providing feedback on the manuscript. The project was sponsored by the Defense Advanced Research Projects Agency (Agreement HR0011-17-2-0008). The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. Author Contributions: Conceptualization and Methodology, NO, AAB, FX, YPL, JCD, and RMM; Formal Analysis, NO, AAB, FX, and YPL; Software, NO, AAB, and YPL; Writing, NO, AAB, and FX; Supervision and Funding, JCD and RMM. The authors declare no competing interests. | ||||||||||||||
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| Record Number: | CaltechAUTHORS:20180927-114225422 | ||||||||||||||
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:20180927-114225422 | ||||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||
| ID Code: | 90015 | ||||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||||
| Deposited By: | George Porter | ||||||||||||||
| Deposited On: | 27 Sep 2018 20:21 | ||||||||||||||
| Last Modified: | 27 Sep 2018 20:54 |
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