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High-resolution imaging using ultrasound-modulated optical tomography

Sakadžić, Sava and Maslov, Konstantin and Li, Jun and Kinra, Vikram K. and Wang, Lihong V. (2004) High-resolution imaging using ultrasound-modulated optical tomography. In: Photons Plus Ultrasound: Imaging and Sensing. Proceedings of SPIE. No.5320. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 150-155. ISBN 9780819452283.

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We present an implementation of ultrasound-modulated optical tomography that has the potential to provide high resolution images of tissue structures at a penetration depth of several millimeters. Light and pulsed ultrasound are focused on an approximately 100 μm wide area below the sample surface. With this configuration, the length of the ultrasonic pulses determines the axial resolution, and the lateral resolution results from the width of the ultrasonic beam at the focus. Diffuse light reflected from the sample is collected into a fiber and the modulated component is separated from the background by a confocal Fabry-Perot interferometer. Using this setup, high contrast images are obtained of 100 μm wide pieces of hair that are buried one millimeter below the surface of the tissue-mimicking sample. It is the first time, to the authors' knowledge, that images with such high resolution have been obtained using ultrasound-modulated optical tomography in the reflection mode.

Item Type:Book Section
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Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2004 Society of Photo-Optical Instrumentation Engineers (SPIE).
Subject Keywords:ultrasonic modulation, acousto-optical tomography, high resolution, multiply scattered light
Series Name:Proceedings of SPIE
Issue or Number:5320
Record Number:CaltechAUTHORS:20180927-114227073
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Official Citation:Sava Sakadzic, Sava Sakadzic, Konstantin Maslov, Konstantin Maslov, Jun Li, Jun Li, Vikram K. Kinra, Vikram K. Kinra, Lihong V. Wang, Lihong V. Wang, } "High-resolution imaging using ultrasound-modulated optical tomography", Proc. SPIE 5320, Photons Plus Ultrasound: Imaging and Sensing, (12 July 2004); doi: 10.1117/12.530890;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90032
Deposited By: George Porter
Deposited On:28 Sep 2018 15:21
Last Modified:16 Nov 2021 00:40

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