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Non-invasive functional photoacoustic tomography of blood-oxygen saturation in the brain

Wang, Xueding and Ku, Geng and Xie, Xueyi and Wang, Yiwen and Stoica, George and Wang, Lihong V. (2004) Non-invasive functional photoacoustic tomography of blood-oxygen saturation in the brain. In: Photons Plus Ultrasound: Imaging and Sensing. Proceedings of SPIE. No.5320. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 69-76. ISBN 9780819452283.

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Since optical contrast is sensitive to functional parameters, including the hemoglobin oxygen saturation and the total concentration of hemoglobin, imaging based on optical contrast has been widely employed for the real-time monitoring of tissue oxygen consumption and hemodynamics in biological tissues. However, due to the overwhelming scattering of light in tissues, traditional optical imaging modalities cannot provide satisfactory spatial resolution. Functional photoacoustic tomography is a novel technique that combines high optical contrast and high ultrasonic resolution. Here, we present our study of a laser-based photoacoustic technique that, for the first time to our knowledge, monitors blood oxygenation in the rat brain in vivo. The cerebral blood oxygenation in the rat brain was imaged by photoacoustic detection at two wavelengths. The change in the hemoglobin oxygen saturation in the brain vessels as a result of the alternation from hyperoxia status to hypoxia status was visualized successfully with satisfactory spatial resolution. This work demonstrates that photoacoustic technique, based on the spectroscopic absorption of oxy- and deoxy-hemoglobin, can provide accurate functional imaging of cerebral blood oxygenation in the small-animal brain non-invasively with the skin and skull intact.

Item Type:Book Section
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Stoica, George0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2004 Society of Photo-Optical Instrumentation Engineers (SPIE).
Subject Keywords:photoacoustic, optoacoustic, spectroscopic absorption, hemoglobin oxygen saturation, cerebral blood oxygenation, functional neuroimaging
Series Name:Proceedings of SPIE
Issue or Number:5320
Record Number:CaltechAUTHORS:20180927-114227252
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Official Citation:Xueding Wang, Xueding Wang, Geng Ku, Geng Ku, Xueyi Xie, Xueyi Xie, Yiwen Wang, Yiwen Wang, George Stoica, George Stoica, Lihong V. Wang, Lihong V. Wang, } "Noninvasive functional photoacoustic tomography of blood-oxygen saturation in the brain", Proc. SPIE 5320, Photons Plus Ultrasound: Imaging and Sensing, (12 July 2004); doi: 10.1117/12.532440;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90034
Deposited By: George Porter
Deposited On:28 Sep 2018 15:40
Last Modified:16 Nov 2021 00:40

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