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A theoretical investigation of human skin thermal response to near-infrared laser irradiation

Dai, Tianhong and Pikkula, Brian M. and Wang, Lihong V. and Anvari, Bahman (2004) A theoretical investigation of human skin thermal response to near-infrared laser irradiation. In: Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV. Proceedings of SPIE. No.5312. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, pp. 7-17. ISBN 9780819452207.

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Near-infrared wavelengths are absorbed less by epidermal melanin mainly located at the basal layer of epidermis (dermo-epidermal junction), and penetrate deeper into human skin dermis and blood than visible wavelengths. Therefore, laser irradiation using near-infrared wavelength may improve the therapeutic outcome of cutaneous hyper-vascular malformations in moderately to heavily pigmented skin patients and those with large-sized blood vessels or blood vessels extending deeply into the skin. A mathematical model composed of a Monte Carlo algorithm to estimate the distribution of absorbed light followed by numerical solution of a bio-heat diffusion equation was utilized to investigate the thermal response of human skin to near-infrared laser irradiation, and compared it with that to visible laser irradiation. Additionally, the effect of skin surface cooling on epidermal protection was theoretically investigated. Simulation results indicated that 940 nm wavelength is superior to 810 and 1064 nm in terms of the ratio of light absorption by targeted blood vessel to the absorption by the basal layer of epidermis, and is more efficient than 595 nm wavelength for the treatment of patients with large-sized blood vessels and moderately to heavily pigmented skin. Dermal blood content has a considerable effect on the laser-induced peak temperature at the basal layer of epidermis, while the effect of blood vessel size is minimum.

Item Type:Book Section
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2004 Society of Photo-Optical Instrumentation Engineers (SPIE). This study was supported in part by grants from the Institute of Arthritis and Musculoskeletal and Skin Disease (IR01-AR47996) at the National Institutes of Health and Texas Higher Education Coordinating Board. We thank Dr. James W. Tunnell from G.R. Harrison Spectroscopy Laboratory at Massachusetts Institute of Technology for his fruitful discussions.
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Texas Higher Education Coordinating BoardUNSPECIFIED
Subject Keywords:Cutaneous hyper-vascular malformations, laser therapy, blood vessel coagulation, epidermal protection
Series Name:Proceedings of SPIE
Issue or Number:5312
Record Number:CaltechAUTHORS:20180927-114227460
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Official Citation:Tianhong Dai, Tianhong Dai, Brian M. Pikkula, Brian M. Pikkula, Lihong V. Wang, Lihong V. Wang, Bahman Anvari, Bahman Anvari, } "A theoretical investigation of human skin thermal response to near-infrared laser irradiation", Proc. SPIE 5312, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, (13 July 2004); doi: 10.1117/12.529146;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90036
Deposited By: George Porter
Deposited On:02 Oct 2018 19:52
Last Modified:03 Oct 2019 20:21

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