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Generation of transgenic birds with replication-deficient lentiviruses

Scott, Benjamin B. and Lois, Carlos (2006) Generation of transgenic birds with replication-deficient lentiviruses. Nature Protocols, 1 . pp. 1406-1411. ISSN 1754-2189. https://resolver.caltech.edu/CaltechAUTHORS:20180928-105832049

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Abstract

Birds are of great interest as an animal model in biological research and for commercial applications as a bioreactor. Effective methods for manipulating the avian genome would accelerate progress in fields such as developmental biology and behavioral neurobiology, which traditionally have relied on birds as model systems for biological research. Here we describe a simple and effective protocol for producing transgenic birds using lentiviral vectors that can be used to achieve tissue-specific transgene expression at high levels. The time allotted for the procedure depends upon the species of bird; adult transgenic quails can be generated in approximately 5 months.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/nprot.2006.187DOIArticle
https://rdcu.be/70JzPublisherFree ReadCube access
ORCID:
AuthorORCID
Lois, Carlos0000-0002-7305-2317
Additional Information:© 2006 Springer Nature Limited. Published 02 November 2006. The authors declare no competing financial interests.
Record Number:CaltechAUTHORS:20180928-105832049
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20180928-105832049
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90051
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Sep 2018 22:11
Last Modified:03 Oct 2019 20:21

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