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Increased Cell-Intrinsic Excitability Induces Synaptic Changes in New Neurons in the Adult Dentate Gyrus That Require Npas4

Sim, Shuyin and Antolin, Salome and Lin, Chia-Wei and Lin, Yingxi and Lois, Carlos (2013) Increased Cell-Intrinsic Excitability Induces Synaptic Changes in New Neurons in the Adult Dentate Gyrus That Require Npas4. Journal of Neuroscience, 33 (18). pp. 7928-7940. ISSN 0270-6474. PMCID PMC3853377. https://resolver.caltech.edu/CaltechAUTHORS:20181001-113520015

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Abstract

Electrical activity regulates the manner in which neurons mature and form connections to each other. However, it remains unclear whether increased single-cell activity is sufficient to alter the development of synaptic connectivity of that neuron or whether a global increase in circuit activity is necessary. To address this question, we genetically increased neuronal excitability of in vivo individual adult-born neurons in the mouse dentate gyrus via expression of a voltage-gated bacterial sodium channel. We observed that increasing the excitability of new neurons in an otherwise unperturbed circuit leads to changes in both their input and axonal synapses. Furthermore, the activity-dependent transcription factor Npas4 is necessary for the changes in the input synapses of these neurons, but it is not involved in changes to their axonal synapses. Our results reveal that an increase in cell-intrinsic activity during maturation is sufficient to alter the synaptic connectivity of a neuron with the hippocampal circuit and that Npas4 is required for activity-dependent changes in input synapses.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/jneurosci.1571-12.2013DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853377/PubMed CentralArticle
https://doi.org/10.1523/JNEUROSCI.2228-13.2013DOICorrection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076770/PubMed CentralCorrection
ORCID:
AuthorORCID
Lois, Carlos0000-0002-7305-2317
Additional Information:© 2013 the Society for Neuroscience. For the first six months after publication SfN’s license will be exclusive. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received March 30, 2012; revised May 9, 2012; accepted March 19, 2013. This work was supported by a NIDCD RO1 Grant to C.L. and funded in part with a grant from the MIT Simons Initiative on Autism and the Brain (Y.L. and C.L.). We thank Alberto Stolfi and Drew Friedman for help with the engineering of the viral constructs, David Clapham (Harvard Medical School, Boston, MA) for providing us with the NaChBac cDNA, and Karl Deisseroth (Stanford University, Palo Alto, CA) for providing the double-floxed inverse ORF vector. The authors declare no competing financial interests.
Errata:Correction: Sim et al., Increased Cell-Intrinsic Excitability Induces Synaptic Changes in New Neurons in the Adult Dentate Gyrus That Require Npas4 Journal of Neuroscience 19 June 2013, 33 (25) 10582; DOI: 10.1523/JNEUROSCI.2228-13.2013
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
MIT Simons Initiative on Autism and the BrainUNSPECIFIED
Issue or Number:18
PubMed Central ID:PMC3853377
Record Number:CaltechAUTHORS:20181001-113520015
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181001-113520015
Official Citation:Increased Cell-Intrinsic Excitability Induces Synaptic Changes in New Neurons in the Adult Dentate Gyrus That Require Npas4 Shuyin Sim, Salome Antolin, Chia-Wei Lin, Yingxi Lin, Carlos Lois Journal of Neuroscience 1 May 2013, 33 (18) 7928-7940; DOI: 10.1523/JNEUROSCI.1571-12.2013
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90058
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:05 Oct 2018 22:56
Last Modified:03 Oct 2019 20:21

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