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Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship

Grover, Surbhi and Martei, Yehoda M. and Puri, Priya and Prabhakar, Pooja and Mutebi, Miriam and Balogun, Onyinye D. and Price, Aryeh J. and Freeman, Alexandra H. and Narasimhamurthy, Mohan and Rodin, Danielle and Rayne, Sarah and Zetola, Nicola M. (2018) Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship. Journal of Global Oncology, 2018 (4). Art. No. 56. ISSN 2378-9506. https://resolver.caltech.edu/CaltechAUTHORS:20181009-095809373

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Abstract

Introduction: The number and lifespan of individuals living with HIV have increased significantly with the scale-up of antiretroviral therapy. Furthermore, the incidence of breast cancer in women with HIV is growing, especially in sub-Saharan Africa (SSA). However, the association between HIV infection and breast cancer is not well understood. Methods: A literature search was performed to identify articles published in journals pertaining to breast cancer and HIV, with an emphasis on SSA. Selected US-based studies were also identified for comparison. Results: Among the 56 studies reviewed, the largest study examined 314 patients with breast cancer and HIV in the United States. There is no consensus on whether HIV infection acts as a pro-oncogenic or antioncogenic factor in breast cancer, and it may have no relation to breast cancer. A higher incidence of breast cancer is reported in high-income countries than in SSA, although breast cancer in SSA presents at a younger age and at a more advanced stage. Some studies show that patients with breast cancer and HIV experience worse chemotherapy toxicity than do patients without HIV. Data on treatment outcomes are limited. The largest study showed worse treatment outcomes in patients with HIV, compared with their counterparts without HIV. Conclusion: HIV infection has not been associated with different clinical presentation of breast cancer. However, some evidence suggests that concurrent diagnosis of HIV with breast cancer is associated with increased therapy-related toxicity and worse outcomes. Systematic prospective studies are needed to establish whether there is a specific association between breast cancer and HIV.


Item Type:Article
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https://doi.org/10.1200/jgo.2016.006585DOIArticle
Additional Information:© 2017 The Author(s). Licensed under the Creative Commons Attribution 4.0 License: https://creativecommons.org/licenses/by/4.0/ Published online January 11, 2017. Data Supplement: Authors retain all rights in any data supplements associated with their articles. The ideas and opinions expressed in this Data Supplement do not necessarily reflect those of the American Society of Clinical Oncology (ASCO). The mention of any product, service, or therapy in this Data Supplement should not be construed as an endorsement of the products mentioned. It is the responsibility of the treating physician or other health care provider, relying on independent experience and knowledge of the patient, to determine drug dosages and the best treatment for the patient. Readers are advised to check the appropriate medical literature and the product information currently provided by the manufacturer of each drug to be administered to verify approved uses, the dosage, method, and duration of administration, or contraindications. Readers are also encouraged to contact the manufacturer with questions about the features or limitations of any products. ASCO and JGO assume no responsibility for any injury or damage to persons or property arising out of or related to any use of the material contained in this publication or to any errors or omissions. Readers should contact the corresponding author with any comments related to Data Supplement materials. Author Contributions: Conception and design: Surbhi Grover, Yehoda M. Martei. Financial support: Surbhi Grover. Administrative support: Surbhi Grover. Provision of study materials or patients: Surbhi Grover, Yehoda M. Martei. Collection and assembly of data: Surbhi Grover, Yehoda M. Martei, Priya Puri, Pooja Prabhakar, Miriam Mutebi, Aryeh J. Price. Data analysis and interpretation: Surbhi Grover, Yehoda M. Martei, Priya Puri, Miriam Mutebi, Onyinye D. Balogun, Aryeh J. Price, Alexandra H. Freeman, Mohan Narasimhamurthy, Danielle Rodin, Sarah Rayne, Nicola M. Zetola. Manuscript writing: All authors. Final approval of manuscript: All authors. Accountable for all aspects of the work: All authors. Author’s Disclosures of Potential Conflicts of Interest: The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc. Surbhi Grover: No relationship to disclose. Yehoda M. Martei: No relationship to disclose. Priya Puri: No relationship to disclose. Pooja Prabhakar: No relationship to disclose. Miriam Mutebi: No relationship to disclose. Onyinye D. Balogun: No relationship to disclose. Aryeh J. Price: Consulting or Advisory Role: Episona, Illumina. Alexandra H. Freeman: No relationship to disclose. Mohan Narasimhamurthy: No relationship to disclose. Danielle Rodin: No relationship to disclose. Sarah Rayne: Travel, Accommodations, Expenses: Novartis. Nicola M. Zetola: No relationship to disclose.
Issue or Number:4
Record Number:CaltechAUTHORS:20181009-095809373
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181009-095809373
Official Citation:Breast Cancer and HIV in Sub-Saharan Africa: A Complex Relationship Surbhi Grover, Yehoda M. Martei, Priya Puri, Pooja Prabhakar, Miriam Mutebi, Onyinye D. Balogun, Aryeh J. Price, Alexandra H. Freeman, Mohan Narasimhamurthy, Danielle Rodin, Sarah Rayne, and Nicola M. Zetola Journal of Global Oncology 2018 :4, 1-11
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90187
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Oct 2018 17:17
Last Modified:03 Oct 2019 20:22

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