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Developmental origin and identity of song system neurons born during vocal learning in songbirds

Scott, Benjamin B. and Lois, Carlos (2007) Developmental origin and identity of song system neurons born during vocal learning in songbirds. Journal of Comparative Neurology, 502 (2). pp. 202-214. ISSN 0021-9967. doi:10.1002/cne.21296. https://resolver.caltech.edu/CaltechAUTHORS:20181010-072753076

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Abstract

New neurons are added to the forebrain song control regions high vocal center (HVC) and Area X of juvenile songbirds but the identity and site of origin of these cells have not been fully characterized. We used oncoretroviral vectors to genetically label neuronal progenitors in different regions of the zebra finch lateral ventricle. A region corresponding to the mammalian medial and lateral ganglionic eminences generated medium spiny neurons found in Area X and in the striatum surrounding Area X, and at least two classes of interneurons found in HVC. In addition, our experiments indicate that the HVC projection neurons that project into nucleus robust nucleus of the arcopallium (RA) are born locally from the ventricular region immediately dorsal to HVC. The ability to genetically target neuron subpopulations that give rise to different song system cell types provides a tool for specific genetic manipulations of these cell types. In addition, our results suggest striking similarities between neurogenesis in the embryonic mammalian brain and in the brain of the juvenile songbird and provide further evidence for the existence of conserved cell types in the forebrain for birds and mammals.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/cne.21296DOIArticle
ORCID:
AuthorORCID
Lois, Carlos0000-0002-7305-2317
Additional Information:© 2007 Wiley‐Liss, Inc. Issue Online: 08 March 2007; Version of Record online: 08 March 2007; Manuscript accepted: 28 December 2006; Manuscript revised: 26 October 2006; Manuscript received: 23 August 2006. Funding Information: Ellison Foundation.
Funders:
Funding AgencyGrant Number
Ellison Medical FoundationUNSPECIFIED
Subject Keywords:neurogenesis; basal ganglia; medium spiny neuron; interneuron; critical period; zebra finch
Issue or Number:2
DOI:10.1002/cne.21296
Record Number:CaltechAUTHORS:20181010-072753076
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181010-072753076
Official Citation:Scott, B. B. and Lois, C. (2007), Developmental origin and identity of song system neurons born during vocal learning in songbirds. J. Comp. Neurol., 502: 202-214. doi:10.1002/cne.21296
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90219
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Oct 2018 17:30
Last Modified:16 Nov 2021 03:30

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