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Effectiveness and Safety of a phototherapeutic contact lens for Diabetic Retinopathy

Yang, Qianhui and Martinez-Camarillo, Juan Carlos and Cook, Colin A. and Scianmarello, Nicholas and Tai, Yu-Chong and Kashani, Amir H. and Humayun, Mark S. (2018) Effectiveness and Safety of a phototherapeutic contact lens for Diabetic Retinopathy. Investigative Ophthalmology and Visual Science, 59 (9). Art. No. 5814. ISSN 0146-0404. https://resolver.caltech.edu/CaltechAUTHORS:20181010-144747080

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Abstract

Purpose : Diabetic retinopathy (DR) is a leading complication of diabetes. It is thought that increased rod metabolism under dark adaptation exacerbates hypoxia in diabetic retina. Nowadays most treatments for DR are invasive and need multiple clinic visits. Recently a phototherapeutic contact lens has been designed to provide illumination to retina as a means to supress dark adaptation. It may be possible to delay the progression of DR. The purpose of this study is to explore the bioactivity and safety of this device. Methods : Six eyes from three healthy mature white New Zealand rabbits were used. The phototherapeutic contact lens was placed on treated eye. An non-phototherapeutic contact lens was used on the fellow eye as a control. To determine bioactivity of photoreceptors, an ERG was performed. Flash response, including amplitude and implicit time on scotopic condition were analyzed at different flash intensities (100, 300, 1000, 3000, 10000, 25000 mcd.s/m^2, respectively). Animals were under a 20-minutes period of dark adaption before any ERG. Then the contact lens were swapped on the eyes and the ERG were repeated. The whole process was performed in a dark room under dim red light. Once ERG were completed, the phototherapeutic contac lens was sutured to the eye for a long–term period (28 days) to verify safety. There will be a statistical analysis using Graph Pad Prism 7.0, determining the degree of correlation between the groups. Histological analysis will be performed to determine safety. Results : The ERG showed that both the amplitude and implicit time of b-wave in the treated eye were significantly shorter than the untreated eye under scotopic conditions (Figure 1). No significant difference in the amplitude and implicit time of a-wave was observed. A representative plot (Figure 2) shows significant depression of b-wave, both in the amplitude and implicit time (amplitude: p=0.01; implicit time: p<0.001). Conclusions : The phototherapeutic contact lens can effectively reduce the bioactivity of the retina, without ocular side effects in an acute follow-up. Further studies should be performed for a long-term placement in both healthy and retinal ischemic animal models to determine whether this device can reduce oxygen consumption in retina and delay disease progression. Long-term histology from contact lens safety is on going and will be presented.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://iovs.arvojournals.org/article.aspx?articleid=2694196&resultClick=1PublisherArticle
ORCID:
AuthorORCID
Cook, Colin A.0000-0002-6283-5105
Tai, Yu-Chong0000-0001-8529-106X
Humayun, Mark S.0000-0002-5830-5208
Additional Information:© 2018 The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Issue or Number:9
Record Number:CaltechAUTHORS:20181010-144747080
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181010-144747080
Official Citation:Qianhui Yang, Juan Carlos Martinez-Camarillo, Colin A. Cook, Nicholas Scianmarello Scianmarello, Yu-Chong Tai, Amir H Kashani, Mark S. Humayun; Effectiveness and Safety of a phototherapeutic contact lens for Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5814
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90236
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Oct 2018 22:13
Last Modified:09 Mar 2020 13:18

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