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Burn depth determination using high-speed polarization-sensitive Mueller optical coherence tomography with continuous polarization modulation

Todorović, Miloš and Ai, Jun and Cubian, David Pereda and Stoica, George and Wang, Lihong (2006) Burn depth determination using high-speed polarization-sensitive Mueller optical coherence tomography with continuous polarization modulation. In: Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X. Proceedings of SPIE. No.6079. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 60792B. ISBN 9780819461216. http://resolver.caltech.edu/CaltechAUTHORS:20181012-103856415

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Abstract

National Health Interview Survey (NHIS) estimates more than 1.1 million burn injuries per year in the United States, with nearly 15,000 fatalities from wounds and related complications. An imaging modality capable of evaluating burn depths non-invasively is the polarization-sensitive optical coherence tomography. We report on the use of a high-speed, fiber-based Mueller-matrix OCT system with continuous source-polarization modulation for burn depth evaluation. The new system is capable of imaging at near video-quality frame rates (8 frames per second) with resolution of 10 μm in biological tissue (index of refraction: 1.4) and sensitivity of 78 dB. The sample arm optics is integrated in a hand-held probe simplifying the in vivo experiments. The applicability of the system for burn depth determination is demonstrated using biological samples of porcine tendon and porcine skin. The results show an improved imaging depth (1 mm in tendon) and a clear localization of the thermally damaged region. The burnt area determined from OCT images compares well with the histology, thus proving the system's potential for burn depth determination.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.649024DOIArticle
ORCID:
AuthorORCID
Stoica, George0000-0001-8071-4828
Wang, Lihong0000-0001-9783-4383
Additional Information:© 2006 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored by the Department of the Army (Cooperative Agreement Number: DAMD17-97-2-7016). The content of the information presented in this paper does not necessarily reflect the position or the policy of the government or NMTB. No official endorsement should be inferred.
Funders:
Funding AgencyGrant Number
Department of the ArmyDAMD17-97-2-7016
Subject Keywords:burn depth, polarization modulation, polarization, OCT, birefringence, phase retardation, Jones matrix, Mueller matrix
Record Number:CaltechAUTHORS:20181012-103856415
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181012-103856415
Official Citation:Miloš Todorović, Miloš Todorović, Jun Ai, Jun Ai, David Pereda Cubian, David Pereda Cubian, George Stoica, George Stoica, Lihong Wang, Lihong Wang, } "Burn depth determination using high-speed polarization-sensitive Mueller optical coherence tomography with continuous polarization modulation", Proc. SPIE 6079, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X, 60792B (20 February 2006); doi: 10.1117/12.649024; https://doi.org/10.1117/12.649024
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90264
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Oct 2018 20:24
Last Modified:12 Oct 2018 20:24

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