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In vivo functional photoacoustic imaging of brain tumor vasculature

Oh, Jung-Taek and Li, Meng-Lin and Xie, Xueyi and Stoica, George and Wang, Lihong V. (2006) In vivo functional photoacoustic imaging of brain tumor vasculature. In: Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6086. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 60860C. ISBN 9780819461285. https://resolver.caltech.edu/CaltechAUTHORS:20181012-135925374

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Abstract

We present a study of the functional photoacoustic imaging of tumor hypoxia in mice in vivo. Based on spectroscopic photoacoustic tomography that detects the optical absorption of oxy- and deoxy-hemoglobins, the blood oxygen saturation and the vascularization of brain tumors were visualized. U87 glioblastoma tumor cells were inoculated intracranially at a 3-mm depth from the surface of the nude mouse head seven days before the experiment. Increased blood content and hypoxia inside the tumor vasculature were detected through the intact skin and skull. This technique will be useful for future studies on tumor metabolic activities in the brain and hypoxia-related therapeutic resistance.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.645391DOIArticle
ORCID:
AuthorORCID
Stoica, George0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2006 Society of Photo-optical Instrumentation Engineers (SPIE).
Subject Keywords:photoacoustic tomography, tumor hypoxia, spectroscopic imaging, blood oxygenation
Series Name:Proceedings of SPIE
Issue or Number:6086
Record Number:CaltechAUTHORS:20181012-135925374
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181012-135925374
Official Citation:Jung-Taek Oh, Jung-Taek Oh, Meng-Lin Li, Meng-Lin Li, Xueyi Xie, Xueyi Xie, George Stoica, George Stoica, Lihong V. Wang, Lihong V. Wang, } "In vivo functional photoacoustic imaging of brain tumor vasculature", Proc. SPIE 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 60860C (6 March 2006); doi: 10.1117/12.645391; https://doi.org/10.1117/12.645391
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90268
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:12 Oct 2018 21:24
Last Modified:03 Oct 2019 20:23

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