Oh, Jung-Taek and Li, Meng-Lin and Xie, Xueyi and Stoica, George and Wang, Lihong V. (2006) In vivo functional photoacoustic imaging of brain tumor vasculature. In: Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6086. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 60860C. ISBN 9780819461285. https://resolver.caltech.edu/CaltechAUTHORS:20181012-135925374
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Abstract
We present a study of the functional photoacoustic imaging of tumor hypoxia in mice in vivo. Based on spectroscopic photoacoustic tomography that detects the optical absorption of oxy- and deoxy-hemoglobins, the blood oxygen saturation and the vascularization of brain tumors were visualized. U87 glioblastoma tumor cells were inoculated intracranially at a 3-mm depth from the surface of the nude mouse head seven days before the experiment. Increased blood content and hypoxia inside the tumor vasculature were detected through the intact skin and skull. This technique will be useful for future studies on tumor metabolic activities in the brain and hypoxia-related therapeutic resistance.
| Item Type: | Book Section | ||||||
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| Additional Information: | © 2006 Society of Photo-optical Instrumentation Engineers (SPIE). | ||||||
| Subject Keywords: | photoacoustic tomography, tumor hypoxia, spectroscopic imaging, blood oxygenation | ||||||
| Series Name: | Proceedings of SPIE | ||||||
| Issue or Number: | 6086 | ||||||
| DOI: | 10.1117/12.645391 | ||||||
| Record Number: | CaltechAUTHORS:20181012-135925374 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20181012-135925374 | ||||||
| Official Citation: | Jung-Taek Oh, Jung-Taek Oh, Meng-Lin Li, Meng-Lin Li, Xueyi Xie, Xueyi Xie, George Stoica, George Stoica, Lihong V. Wang, Lihong V. Wang, } "In vivo functional photoacoustic imaging of brain tumor vasculature", Proc. SPIE 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 60860C (6 March 2006); doi: 10.1117/12.645391; https://doi.org/10.1117/12.645391 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 90268 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 12 Oct 2018 21:24 | ||||||
| Last Modified: | 16 Nov 2021 03:31 |
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