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Concise Reviews: Stem Cells and Kidney Regeneration: An Update

Marcheque, Julia and Bussolati, Benedetta and Csete, Marie and Perin, Laura (2019) Concise Reviews: Stem Cells and Kidney Regeneration: An Update. Stem Cells Translational Medicine, 8 (1). pp. 82-92. ISSN 2157-6564. doi:10.1002/sctm.18-0115.

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Significant progress has been made to advance stem cell products as potential therapies for kidney diseases: various kinds of stem cells can restore renal function in preclinical models of acute and chronic kidney injury. Nonetheless this literature contains contradictory results, and for this reason, we focus this review on reasons for apparent discrepancies in the literature, because they contribute to difficulty in translating renal regenerative therapies. Differences in methodologies used to derive and culture stem cells, even those from the same source, in addition to the lack of standardized renal disease animal models (both acute and chronic), are important considerations underlying contradictory results in the literature. We propose that harmonized rigorous protocols for characterization, handling, and delivery of stem cells in vivo could significantly advance the field, and present details of some suggested approaches to foster translation in the field of renal regeneration. Our goal is to encourage coordination of methodologies (standardization) and long‐lasting collaborations to improve protocols and models to lead to reproducible, interpretable, high‐quality preclinical data. This approach will certainly increase our chance to 1 day offer stem cell therapeutic options for patients with all‐too‐common renal diseases.

Item Type:Article
Related URLs:
URLURL TypeDescription
Bussolati, Benedetta0000-0002-3663-5134
Csete, Marie0000-0003-4591-0510
Perin, Laura0000-0002-6955-6416
Additional Information:© 2018 The Authors. Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. Version of Record online: 09 October 2018; Manuscript accepted: 03 August 2018; Manuscript received: 24 May 2018. Author Contributions: J.M.: data analysis and interpretation, manuscript writing; B.B.: data analysis and interpretation, manuscript writing; M.C.: conception and design, manuscript writing; L.P: conception and design, manuscript writing, and final approval. The authors declared no conflict of interest.
Subject Keywords:Adult stem cells; Kidney; Mesenchymal stem cells; Renal
Issue or Number:1
Record Number:CaltechAUTHORS:20181022-111829073
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Official Citation:Marcheque, J. , Bussolati, B. , Csete, M. and Perin, L. (2019), Concise Reviews: Stem Cells and Kidney Regeneration: An Update. STEM CELLS Translational Medicine, 8: 82-92. doi:10.1002/sctm.18-0115
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90325
Deposited By: Tony Diaz
Deposited On:22 Oct 2018 20:50
Last Modified:16 Nov 2021 03:31

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