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Radiosensitization by a Pyrrole-Imidazole Polyamide Through Interference with DNA Repair

Diaz-Perez, S. and Kane, N. and Yang, F. and Kurmis, A. A. and Kummer, N. T., Jr. and Dervan, P. B. and Nickols, N. (2018) Radiosensitization by a Pyrrole-Imidazole Polyamide Through Interference with DNA Repair. International Journal of Radiation Oncology Biology Physics, 102 (3, Supp.). e155. ISSN 0360-3016. http://resolver.caltech.edu/CaltechAUTHORS:20181022-155441897

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Abstract

Non-genotoxic small molecules that potentiate the effects of ionizing radiation in malignant cells could be used to augment radiotherapy for solid tumors. Pyrrole-imidazole (PyeIm) polyamides are synthetic non-genotoxic DNA minor groove-binding small molecules with programmable sequence specificity; binding to DNA induces allosteric changes that can interfere with protein-DNA interactions. We hypothesized that PyeIm polyamides can modulate the cellular response to ionizing radiation.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.ijrobp.2018.07.604DOIArticle
https://www.redjournal.org/article/S0360-3016(18)32058-3/fulltextPublisherArticle
Additional Information:© 2018 Published by Elsevier Inc. Available online 20 October 2018. Author Disclosure: S. Diaz-Perez: None. N. Kane: None. F. Yang: stock and patents; GeneSciences Inc. A.A. Kurmis: None. N.T. Kummer: None. P.B. Dervan: stock and patents; GeneSciences Inc. N. Nickols: Research Grant; PCF, Bayer. stock, patents; GeneSciences Inc.
Record Number:CaltechAUTHORS:20181022-155441897
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181022-155441897
Official Citation:S. Diaz-Perez, N. Kane, F. Yang, A.A. Kurmis, N.T. Kummer, P.B. Dervan, N. Nickols, Radiosensitization by a Pyrrole-Imidazole Polyamide Through Interference with DNA Repair, International Journal of Radiation Oncology*Biology*Physics, Volume 102, Issue 3, Supplement, 2018, Page e155, ISSN 0360-3016, https://doi.org/10.1016/j.ijrobp.2018.07.604. (http://www.sciencedirect.com/science/article/pii/S0360301618320583)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90335
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Oct 2018 22:05
Last Modified:25 Mar 2019 22:50

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