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Selective C_H bond functionalization with engineered heme proteins: new tools to generate complexity

Zhang, Ruijie K. and Huang, Xiongyi and Arnold, Frances H. (2019) Selective C_H bond functionalization with engineered heme proteins: new tools to generate complexity. Current Opinion in Chemical Biology, 49 . pp. 67-75. ISSN 1367-5931. PMCID PMC6461521. http://resolver.caltech.edu/CaltechAUTHORS:20181029-094838266

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Abstract

C-H functionalization is an attractive strategy to construct and diversify molecules. Heme proteins, predominantly cytochromes P450, are responsible for an array of C-H oxidations in biology. Recent work has coupled concepts from synthetic chemistry, computation, and natural product biosynthesis to engineer heme protein systems to deliver products with tailored oxidation patterns. Heme protein catalysis has been shown to go well beyond these native reactions and now accesses new-to-nature C-H transformations, including C-N and C-C bond forming processes. Emerging work with these systems moves us along the ambitious path of building complexity from the ubiquitous C-H bond.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.cbpa.2018.10.004DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461521/PubMed CentralArticle
ORCID:
AuthorORCID
Huang, Xiongyi0000-0001-7156-8881
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 2018 Elsevier. Available online 18 October 2018. This work was supported by the NSF, Division of Molecular and Cellular Biosciences (grant MCB-1513007). R. K. Z. acknowledges support from the NSF Graduate Research Fellowship (grant DGE-1144469) and the Donna and Benjamin M. Rosen Bioengineering Center. X. H. is supported by an NIH pathway to independence award (grant K99GM129419). Conflict of interest statement: Nothing declared.
Group:Rosen Bioengineering Center
Funders:
Funding AgencyGrant Number
Donna and Benjamin M. Rosen Bioengineering CenterUNSPECIFIED
NSFMCB-1513007
NSF Graduate Research FellowshipDGE-1144469
NIHK99GM129419
PubMed Central ID:PMC6461521
Record Number:CaltechAUTHORS:20181029-094838266
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181029-094838266
Official Citation:Ruijie K Zhang, Xiongyi Huang, Frances H Arnold, Selective CH bond functionalization with engineered heme proteins: new tools to generate complexity, Current Opinion in Chemical Biology, Volume 49, 2019, Pages 67-75, ISSN 1367-5931, https://doi.org/10.1016/j.cbpa.2018.10.004. (http://www.sciencedirect.com/science/article/pii/S1367593118301431)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90453
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:29 Oct 2018 17:58
Last Modified:17 Jun 2019 16:48

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