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Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality

Kinkhabwala, Amina A. and Gu, Yi and Aronov, Dmitriy and Tank, David W. (2018) Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality. . (Unpublished) http://resolver.caltech.edu/CaltechAUTHORS:20181029-151552539

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Abstract

During spatial navigation, animals use self-motion to estimate positions through path integration. However, estimation errors accumulate over time and it is unclear how they are corrected. Here we report a new cell class, cue cell, in mouse medial entorhinal cortex (MEC) that encoded visual cue information that could be used to correct errors in path integration. Cue cells accounted for a large fraction of unidentified MEC cells. They exhibited firing fields only near visual cues during virtual navigation and spatially stable activity during navigation in a real arena. Cue cells' responses occurred in sequences repeated at each cue and were likely driven by visual inputs. In layers 2/3 of the MEC, cue cells formed clusters. Anatomically adjacent cue cells responded similarly to cues. These cue cell properties demonstrate that the MEC circuits contain a code representing spatial landmarks that could play a significant role in error correction during path integration.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/453787DOIDiscussion Paper
ORCID:
AuthorORCID
Tank, David W.0000-0002-9423-4267
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. bioRxiv preprint first posted online Oct. 25, 2018. We thank current and former members of the Tank lab, Ila Fiete, and Anika Kinkhabwala for helpful discussions, and Jeffrey Santner and Alexander Riordan for comments on the manuscript. This work was supported by NINDS Grant 5R37NS081242 (D.W.T), NIMH Grant 5R01MH083686 (D.W.T), NIH Postdoctoral Fellowship Grant F32NS070514-01A1 (A.A.K). The authors declare no competing interests.
Funders:
Funding AgencyGrant Number
NIH5R37NS081242
NIH5R01MH083686
NIH Postdoctoral FellowshipF32NS070514-01A1
Record Number:CaltechAUTHORS:20181029-151552539
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181029-151552539
Official Citation:Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality. Amina Kinkhabwala, Yi Gu, Dmitriy Aronov, David W Tank. bioRxiv 453787; doi: https://doi.org/10.1101/453787
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90479
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:30 Oct 2018 01:52
Last Modified:30 Oct 2018 01:52

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