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Structural insight into the protein translocation channel

Clemons, William M., Jr. and Ménétret, Jean-François and Akey, Christopher W. and Rapoport, Tom A. (2004) Structural insight into the protein translocation channel. Current Opinion in Structural Biology, 14 (4). pp. 390-396. ISSN 0959-440X. https://resolver.caltech.edu/CaltechAUTHORS:20181101-114159682

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Abstract

A structurally conserved protein translocation channel is formed by the heterotrimeric Sec61 complex in eukaryotes, and SecY complex in archaea and bacteria. Electron microscopy studies suggest that the channel may function as an oligomeric assembly of Sec61 or SecY complexes. Remarkably, the recently determined X-ray structure of an archaeal SecY complex indicates that the pore is located at the center of a single molecule of the complex. This structure suggests how the pore opens perpendicular to the plane of the membrane to allow the passage of newly synthesized secretory proteins across the membrane and opens laterally to allow transmembrane segments of nascent membrane proteins to enter the lipid bilayer. The electron microscopy and X-ray results together suggest that only one copy of the SecY or Sec61 complex within an oligomer translocates a polypeptide chain at any given time.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.sbi.2004.07.006DOIArticle
ORCID:
AuthorORCID
Clemons, William M., Jr.0000-0002-0021-889X
Additional Information:© 2004 Elsevier. Available online 21 July 2004. We thank AR Osborne and B van den Berg for critical reading of the manuscript. WMC was supported by a Damon-Runyon Cancer Research Foundation fellowship. Both TAR and CWA are supported by National Institutes of Health grants. TAR is an investigator of the Howard Hughes Medical Institute.
Funders:
Funding AgencyGrant Number
Damon Runyon Cancer Research FoundationUNSPECIFIED
NIHUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20181101-114159682
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181101-114159682
Official Citation:William M Clemons, Jean-François Ménétret, Christopher W Akey, Tom A Rapoport, Structural insight into the protein translocation channel, Current Opinion in Structural Biology, Volume 14, Issue 4, 2004, Pages 390-396, ISSN 0959-440X, https://doi.org/10.1016/j.sbi.2004.07.006. (http://www.sciencedirect.com/science/article/pii/S0959440X04001137)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90565
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:01 Nov 2018 19:57
Last Modified:03 Oct 2019 20:26

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