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The process of infection with bacteriophage phiX174, XXI. Replication and fate of the replicative form

Knippers, Rolf and Komano, Tohru and Sinsheimer, Robert L. (1968) The process of infection with bacteriophage phiX174, XXI. Replication and fate of the replicative form. Proceedings of the National Academy of Sciences of the United States of America, 59 (2). pp. 577-581. ISSN 0027-8424. PMCID PMC224711.

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Previous publications have described the formation of a double-stranded DNA intermediate(1) (replicative form, RF) during the replication of bacteriophage phiX174, the semiconservative replication at a bacterial "site"(2) of that RF containing the parental DNA strand,(3,4) and the persistence of the parental DNA strand at the site, accompanied by the release of the daughter RF.(5) The nascent RF molecules first appear as RFII,(6,7) and are rapidly converted to RFI. This paper considers the structure of the nascent RF molecules in more detail and inquires into the fate of the daughter RF molecules during the subsequent period of progeny single-strand DNA formation. A succeeding paper(8) will consider the process of formation of the progeny single-strands.

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Additional Information:© 1968 by the National Academy of Sciences. Communicated December 11, 1967. Supported in part by grant GM13554 from the U.S. Public Health Service. We are indebted tp Dr. M. Azegami for a gift of P32-phiX-DNA.
Issue or Number:2
PubMed Central ID:PMC224711
Record Number:CaltechAUTHORS:KNIpnas68
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9063
Deposited By: Tony Diaz
Deposited On:25 Oct 2007
Last Modified:02 Oct 2019 23:56

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