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Defining Dysbiosis in Disorders of Movement and Motivation

Fields, Christopher T. and Sampson, Timothy R. and Bruce-Keller, Annadora J. and Kiraly, Drew D. and Hsiao, Elaine Y. and de Vries, Geert J. (2018) Defining Dysbiosis in Disorders of Movement and Motivation. Journal of Neuroscience, 38 (44). pp. 9414-9422. ISSN 0270-6474. PMCID PMC6209841. doi:10.1523/jneurosci.1672-18.2018.

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The gut microbiota has emerged as a critical player in shaping and modulating brain function and has been shown to influence numerous behaviors, including anxiety and depression-like behaviors, sociability, and cognition. However, the effects of the gut microbiota on specific disorders associated with thalamo-cortico-basal ganglia circuits, ranging from compulsive behavior and addiction to altered sensation and motor output, are only recently being explored. Wholesale depletion and alteration of gut microbial communities in rodent models of disorders, such as Parkinson's disease, autism, and addiction, robustly affect movement and motivated behavior. A new frontier therefore lies in identifying specific microbial alterations that affect these behaviors and understanding the underlying mechanisms of action. Comparing alterations in gut microbiota across multiple basal-ganglia associated disease states allows for identification of common mechanistic pathways that may interact with distinct environmental and genetic risk factors to produce disease-specific outcomes.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Fields, Christopher T.0000-0002-2054-7316
Sampson, Timothy R.0000-0002-2486-8766
Kiraly, Drew D.0000-0002-4818-5169
Hsiao, Elaine Y.0000-0002-1633-588X
Additional Information:© 2018 the authors. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license ( Received Sept. 5, 2018; revised Sept. 28, 2018; accepted Sept. 28, 2018. This work was supported by National Institute of Health Grants MH112369 to C.T.F., MH110117 to A.J.B.-K., DA044308 to D.D.K., OD017924 to E.Y.H., and MH108345 to G.J.d.V.; the Brain and Behavior Research Foundation to D.D.K.; the Larry L. Hillblom Foundation to T.R.S.; and the Office of Naval Research, Multidisciplinary University Research Initiative to E.Y.H. The authors declare no competing financial interests.
Funding AgencyGrant Number
Brain and Behavior Research FoundationUNSPECIFIED
Larry L. Hillblom FoundationUNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
Subject Keywords:gut microbiota; basal ganglia; compulsive behavior; motor function; Parkinson's; addiction
Issue or Number:44
PubMed Central ID:PMC6209841
Record Number:CaltechAUTHORS:20181105-100651058
Persistent URL:
Official Citation:Defining Dysbiosis in Disorders of Movement and Motivation. Christopher T. Fields, Timothy R. Sampson, Annadora J. Bruce-Keller, Drew D. Kiraly, Elaine Y. Hsiao, Geert J. de Vries. Journal of Neuroscience 31 October 2018, 38 (44) 9414-9422; DOI: 10.1523/JNEUROSCI.1672-18.2018
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90636
Deposited By: Tony Diaz
Deposited On:06 Nov 2018 17:34
Last Modified:16 Nov 2021 03:34

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