Fields, Christopher T. and Sampson, Timothy R. and Bruce-Keller, Annadora J. and Kiraly, Drew D. and Hsiao, Elaine Y. and de Vries, Geert J. (2018) Defining Dysbiosis in Disorders of Movement and Motivation. Journal of Neuroscience, 38 (44). pp. 9414-9422. ISSN 0270-6474. PMCID PMC6209841. doi:10.1523/jneurosci.1672-18.2018. https://resolver.caltech.edu/CaltechAUTHORS:20181105-100651058
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Abstract
The gut microbiota has emerged as a critical player in shaping and modulating brain function and has been shown to influence numerous behaviors, including anxiety and depression-like behaviors, sociability, and cognition. However, the effects of the gut microbiota on specific disorders associated with thalamo-cortico-basal ganglia circuits, ranging from compulsive behavior and addiction to altered sensation and motor output, are only recently being explored. Wholesale depletion and alteration of gut microbial communities in rodent models of disorders, such as Parkinson's disease, autism, and addiction, robustly affect movement and motivated behavior. A new frontier therefore lies in identifying specific microbial alterations that affect these behaviors and understanding the underlying mechanisms of action. Comparing alterations in gut microbiota across multiple basal-ganglia associated disease states allows for identification of common mechanistic pathways that may interact with distinct environmental and genetic risk factors to produce disease-specific outcomes.
Item Type: | Article | ||||||||||||||||||
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Additional Information: | © 2018 the authors. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received Sept. 5, 2018; revised Sept. 28, 2018; accepted Sept. 28, 2018. This work was supported by National Institute of Health Grants MH112369 to C.T.F., MH110117 to A.J.B.-K., DA044308 to D.D.K., OD017924 to E.Y.H., and MH108345 to G.J.d.V.; the Brain and Behavior Research Foundation to D.D.K.; the Larry L. Hillblom Foundation to T.R.S.; and the Office of Naval Research, Multidisciplinary University Research Initiative to E.Y.H. The authors declare no competing financial interests. | ||||||||||||||||||
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Subject Keywords: | gut microbiota; basal ganglia; compulsive behavior; motor function; Parkinson's; addiction | ||||||||||||||||||
Issue or Number: | 44 | ||||||||||||||||||
PubMed Central ID: | PMC6209841 | ||||||||||||||||||
DOI: | 10.1523/jneurosci.1672-18.2018 | ||||||||||||||||||
Record Number: | CaltechAUTHORS:20181105-100651058 | ||||||||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20181105-100651058 | ||||||||||||||||||
Official Citation: | Defining Dysbiosis in Disorders of Movement and Motivation. Christopher T. Fields, Timothy R. Sampson, Annadora J. Bruce-Keller, Drew D. Kiraly, Elaine Y. Hsiao, Geert J. de Vries. Journal of Neuroscience 31 October 2018, 38 (44) 9414-9422; DOI: 10.1523/JNEUROSCI.1672-18.2018 | ||||||||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||||||
ID Code: | 90636 | ||||||||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||||||||
Deposited By: | Tony Diaz | ||||||||||||||||||
Deposited On: | 06 Nov 2018 17:34 | ||||||||||||||||||
Last Modified: | 16 Nov 2021 03:34 |
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