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Functional photoacoustic microscopy in vivo

Zhang, Hao F. and Maslov, Konstantin and Oh, Jung-Taek and Stoica, George and Wang, Lihong V. (2006) Functional photoacoustic microscopy in vivo. In: Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6086. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 60861G. ISBN 9780819461285. https://resolver.caltech.edu/CaltechAUTHORS:20181107-084323302

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Abstract

Functional photoacoustic microscopy is a hybrid imaging technique that detects laser induced photoacoustic waves to image biological tissues in three dimensions. Its imaging depth exceeds the fundamental depth limit of the existing high resolution optical imaging modalities while maintaining a comparable ratio of imaging depth to axial resolution. The amplitude of photoacoutic waves is related to tissue's optical absorption and, therefore, functional imaging can be achieved by acquiring spectroscopic information. We demonstrate here the capabilities of functional photoacoustic microscopy by volumetric imaging a skin melanoma tumor and functional imaging of hemoglobin oxygen saturation in single vessels in vivo.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.645143DOIArticle
ORCID:
AuthorORCID
Maslov, Konstantin0000-0003-3408-8840
Stoica, George0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2006 Society of Photo-optical Instrumentation Engineers (SPIE). We thank Ovidiu Craciun, Geng Ku, Meng-lin Li, and Gina Lungu for experimental assistance. This project is sponsored by National Institutes of Health grants R01 EB000712 and R01 NS46214.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
Subject Keywords:Photoacoustic, microscopy, melanoma, hemoglobin, oxygenation
Series Name:Proceedings of SPIE
Issue or Number:6086
Record Number:CaltechAUTHORS:20181107-084323302
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181107-084323302
Official Citation:Hao F. Zhang, Konstantin Maslov, Jung-Taek Oh, George Stoica, Lihong V. Wang, } "Functional photoacoustic microscopy in vivo", Proc. SPIE 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 60861G (6 March 2006); doi: 10.1117/12.645143; https://doi.org/10.1117/12.645143
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90691
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:07 Nov 2018 17:51
Last Modified:03 Mar 2020 13:01

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