Zemp, Roger J. and Li, Li and Wang, Lihong V. (2006) Fundamental considerations for multiwavelength photoacoustic molecular imaging. In: Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics. Proceedings of SPIE. No.6086. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 60861L. ISBN 9780819461285. https://resolver.caltech.edu/CaltechAUTHORS:20181107-084753789
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Abstract
Photoacoustic technology offers great promise for molecular imaging in vivo since it offers significant penetration, and optical contrast with ultrasonic spatial resolution. In this article we examine fundamental technical issues impacting capabilities of photoacoustic tomography for molecular imaging. First we examine how reconstructed photoacoustic tomography images are related to true absorber distributions by studying the modulation transfer function of a circular scanning tomographic system employing a modified filtered backprojection algorithm. We then study factors influencing quantitative estimation by developing a forward model of photoacoustic signal generation, and show conditions for which the system of equations can be inverted. Errors in the estimated optical fluence are shown to be a source of bias in estimates of molecular agent concentration. Finally we discuss noise propagation through the matrix inversion procedure and discuss implications for molecular imaging sensitivity and system design.
| Item Type: | Book Section | ||||||
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| Additional Information: | © 2006 Society of Photo-optical Instrumentation Engineers (SPIE). We appreciate fruitful discussions with Dr. Konstantin Maslov. We gratefully acknowledge funding from the National Institutes of Health R01 NS46214 and R01 EB000712. | ||||||
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| Series Name: | Proceedings of SPIE | ||||||
| Issue or Number: | 6086 | ||||||
| DOI: | 10.1117/12.646392 | ||||||
| Record Number: | CaltechAUTHORS:20181107-084753789 | ||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20181107-084753789 | ||||||
| Official Citation: | Roger J. Zemp, Li Li, Lihong V. Wang, } "Fundamental considerations for multiwavelength photoacoustic molecular imaging", Proc. SPIE 6086, Photons Plus Ultrasound: Imaging and Sensing 2006: The Seventh Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, 60861L (6 March 2006); doi: 10.1117/12.646392; https://doi.org/10.1117/12.646392 | ||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
| ID Code: | 90692 | ||||||
| Collection: | CaltechAUTHORS | ||||||
| Deposited By: | Tony Diaz | ||||||
| Deposited On: | 07 Nov 2018 17:50 | ||||||
| Last Modified: | 16 Nov 2021 03:34 |
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