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A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex

Gu, Yi and Lewallen, Sam and Kinkhabwala, Amina A. and Domnisoru, Cristina and Yoon, Kijung and Gauthier, Jeffrey L. and Fiete, Ila R. and Tank, David W. (2018) A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex. Cell, 175 (3). pp. 736-750. ISSN 0092-8674. http://resolver.caltech.edu/CaltechAUTHORS:20181108-090635057

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Abstract

How the topography of neural circuits relates to their function remains unclear. Although topographic maps exist for sensory and motor variables, they are rarely observed for cognitive variables. Using calcium imaging during virtual navigation, we investigated the relationship between the anatomical organization and functional properties of grid cells, which represent a cognitive code for location during navigation. We found a substantial degree of grid cell micro-organization in mouse medial entorhinal cortex: grid cells and modules all clustered anatomically. Within a module, the layout of grid cells was a noisy two-dimensional lattice in which the anatomical distribution of grid cells largely matched their spatial tuning phases. This micro-arrangement of phases demonstrates the existence of a topographical map encoding a cognitive variable in rodents. It contributes to a foundation for evaluating circuit models of the grid cell network and is consistent with continuous attractor models as the mechanism of grid formation.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.cell.2018.08.066DOIArticle
ORCID:
AuthorORCID
Tank, David W.0000-0002-9423-4267
Additional Information:© 2018 Elsevier Inc. Received 7 February 2018, Revised 31 July 2018, Accepted 29 August 2018, Available online 27 September 2018. Published: September 27, 2018; corrected online October 5, 2018. We thank Yao Lu, Alex Riordan, Dr. Rong Gong, and Dr. Ben Scott for comments on the manuscript, and Dr. Gary Laevsky for help with confocal microscopy. This work was supported by the NIH (grant 5R37NS081242 to D.W.T.) and the Simons Foundation (Simons Collaboration on the Global Brain [SCGB]). Author Contributions: Y.G. and D.W.T. conceived the project and wrote the manuscript with contributions from I.R.F., C.D., and S.L. Y.G. performed two-photon experiments. Y.G. and S.L. applied the folding triangle analysis and global lattice fit developed by S.L. Y.G. performed all other analyses. A.A.K. performed tetrode experiments. Y.G. and C.D. developed the brute-force grid cell fitter. J.L.G. developed ROI extraction methods. K.Y. provided phase analysis advice and MATLAB code for calculating grid scores. The authors declare no competing interests.
Funders:
Funding AgencyGrant Number
NIH5R37NS081242
Simons FoundationUNSPECIFIED
Subject Keywords:medial entorhinal cortex; grid cell; grid module; grid phase; pyramidal cell; stellate cell; calcium imaging; microprism; virtual reality; continuous attractor network models
Record Number:CaltechAUTHORS:20181108-090635057
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20181108-090635057
Official Citation:Yi Gu, Sam Lewallen, Amina A. Kinkhabwala, Cristina Domnisoru, Kijung Yoon, Jeffrey L. Gauthier, Ila R. Fiete, David W. Tank, A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal Cortex, Cell, Volume 175, Issue 3, 2018, Pages 736-750.e30, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2018.08.066. (http://www.sciencedirect.com/science/article/pii/S009286741831167X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90743
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:08 Nov 2018 20:59
Last Modified:08 Nov 2018 20:59

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