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Development of nickel-catalyzed asymmetric reductive cross-couplings

Hofstra, Julie (2018) Development of nickel-catalyzed asymmetric reductive cross-couplings. In: 256th American Chemical Society National Meeting & Exposition, 19-23 August 2018, Boston, MA. https://resolver.caltech.edu/CaltechAUTHORS:20181108-145518685

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Abstract

Cross-coupling reactions have emerged as powerful methods to form carbon-carbon and carbon-heteroatom bonds in a vast array of synthetic contexts. Nickel-catalyzed reductive cross-coupling reactions have opened up a new mode of reactivity, allowing for the cross-coupling of bench-stable electrophiles as both coupling partners. Asym. variants, which proceed with the use of a chiral ligand, increase mol. complexity by introducing newly formed stereocenters with high levels of enantioselectivity. Application of this methodol. to a wide array of electrophiles has led to the development of a no. of asym. transformations incorporating both C(sp2)-hybridized electrophiles (aryl iodides, alkenyl bromides, and acyl chlorides) and C(sp3)-hybridized electrophiles (benzyl chlorides and α-chloronitriles). Here we will discuss our most recent efforts in the development and application of these cross-coupling reactions.


Item Type:Conference or Workshop Item (Paper)
Related URLs:
URLURL TypeDescription
https://global.acs.org/events/256th-acs-national-meeting-expositionOrganizationConference Website
ORCID:
AuthorORCID
Hofstra, Julie0000-0001-9558-4317
Additional Information:© 2018 American Chemical Society.
Record Number:CaltechAUTHORS:20181108-145518685
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181108-145518685
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90770
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Nov 2018 17:56
Last Modified:03 Oct 2019 20:28

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