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Label-free single-molecule all-optical sensor

Armani, Andrea M. and Fraser, Scott E. and Flagan, Richard C. (2008) Label-free single-molecule all-optical sensor. In: Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VIII. Proceedings of SPIE. No.6852. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 68520A. ISBN 9780819470270. https://resolver.caltech.edu/CaltechAUTHORS:20181109-123900933

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Abstract

Recently, quality factors greater than 100 million were demonstrated using planar arrays of silica microtoroid resonators. These high Q factors allow the toroidal resonators to perform very sensitive detection experiments. By functionalizing the silica surface of the toroid with biotin, the toroidal resonators become both specific and sensitive detectors for Streptavidin. One application of this sensor is performing detection in lysates. To mimic this type of environment, additional solutions of Streptavidin were prepared which also contained high concentrations (nM and μM) of tryptophan.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.761007DOIArticle
ORCID:
AuthorORCID
Armani, Andrea M.0000-0001-9890-5104
Fraser, Scott E.0000-0002-5377-0223
Flagan, Richard C.0000-0001-5690-770X
Additional Information:© 2008 Society of Photo-optical Instrumentation Engineers (SPIE). The authors would like to thank Dr. Rajan Kulkarni for numerous helpful discussions. A.M. Armani is supported by a Clare Boothe Luce Post-doctoral Fellowship. This work was supported by the DARPA Center for OptoFluidic Integration.
Funders:
Funding AgencyGrant Number
Clare Boothe Luce Postdoctoral FellowshipUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Series Name:Proceedings of SPIE
Issue or Number:6852
DOI:10.1117/12.761007
Record Number:CaltechAUTHORS:20181109-123900933
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181109-123900933
Official Citation:Andrea M. Armani, Scott E. Fraser, Richard C. Flagan, } "Label-free single-molecule all-optical sensor", Proc. SPIE 6852, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VIII, 68520A (7 February 2008); doi: 10.1117/12.761007; https://doi.org/10.1117/12.761007
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90798
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Nov 2018 22:34
Last Modified:16 Nov 2021 03:35

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