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Label-free detection of cytokines using optical microcavities

Armani, Andrea M. and Fraser, Scott E. (2008) Label-free detection of cytokines using optical microcavities. In: Single Molecule Spectroscopy and Imaging. Proceedings of SPIE. No.6862. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 68620C. ISBN 9780819470379.

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Ultra-high-Q microresonators have demonstrated sensitive and specific chemical and biological detection. The sensitivity is derived from the long photon lifetime inside the cavity and specificity is achieved through surface functionalization. Here, ultra-high-Q microcavities demonstrate label-free, single molecule detection of Interleukin-2 (IL-2) in fetal bovine serum (FBS). IL-2 is a cytokine released in response to immune system activation. The surface of the microtoroids was sensitized using anti-IL-2. The detection mechanism relies upon a thermo-optic mechanism to enhance resonant wavelength shifts induced through binding of a molecule.

Item Type:Book Section
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URLURL TypeDescription
Armani, Andrea M.0000-0001-9890-5104
Fraser, Scott E.0000-0002-5377-0223
Additional Information:© 2008 Society of Photo-optical Instrumentation Engineers (SPIE). The authors would like to thank Prof. Richard Flagan and Dr. Rajan Kulkarni, for numerous helpful discussions. A.M. Armani is supported by a Clare Boothe Luce Post-doctoral Fellowship. This work was supported by the DARPA Center for OptoFluidic Integration.
Funding AgencyGrant Number
Clare Boothe Luce Postdoctoral FellowshipUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Series Name:Proceedings of SPIE
Issue or Number:6862
Record Number:CaltechAUTHORS:20181109-125349088
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Official Citation:Andrea M. Armani, Scott E. Fraser, } "Label-free detection of cytokines using optical microcavities", Proc. SPIE 6862, Single Molecule Spectroscopy and Imaging, 68620C (21 February 2008); doi: 10.1117/12.761002;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90800
Deposited By: Tony Diaz
Deposited On:14 Nov 2018 19:13
Last Modified:16 Nov 2021 03:35

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