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Understanding and improving membrane protein expression in cells

Miller, Thomas (2018) Understanding and improving membrane protein expression in cells. In: 256th American Chemical Society National Meeting & Exposition, 19-23 August 2018, Boston, MA.

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Although proteins are synthesized only in specialized cellular locations, they are destined for delivery to all corners of the cell-and beyond. A key step in this delivery process is the efficient transport, or translocation, of the newly synthesized proteins across cell membranes, which involves a delicate balance between mol. processes. Recent studies offer highresoln. glimpses into the translocation process, but many fundamental aspects of its mechanism and regulation remain poorly understood. I will present our lab's efforts to computationally simulate the protein translocation process and to predict ways of controlling the in vivo targeting and delivery of proteins. This work employs methods that span across atomistic simulation, coarse-grained methods, machine learning techniques, and exptl. collaborations.

Item Type:Conference or Workshop Item (Paper)
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Miller, Thomas0000-0002-1882-5380
Additional Information:© 2018 American Chemical Society.
Record Number:CaltechAUTHORS:20181109-145636147
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90806
Deposited By: Tony Diaz
Deposited On:14 Nov 2018 19:07
Last Modified:03 Oct 2019 20:28

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