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Electrical activity in cerebellar cultures determines Purkinje cell dendritic growth patterns

Schilling, Karl and Dickinson, Michael H. and Connor, John A. and Morgan, James I. (1991) Electrical activity in cerebellar cultures determines Purkinje cell dendritic growth patterns. Neuron, 7 (6). pp. 891-902. ISSN 0896-6273. https://resolver.caltech.edu/CaltechAUTHORS:20181115-155829070

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Abstract

In primary dissociated cultures of mouse cerebellum a number of Purkinje cell-specific marker proteins and characteristic ionic currents appear at the appropriate developmental time. During the first week after plating, Purkinje cell dendrites elongate, but as electrical activity emerges the dendrites stop growing and branch. If endogenous electrical activity is inhibited by chronic tetrodotoxin or high magnesium treatment, dendrites continue to elongate, as if they were still immature. At the time that branching begins, intracellular calcium levels become sensitive to tetrodotoxin, suggesting that this cation may be involved in dendrite growth. Even apparently mature Purkinje cells alter their dendritic growth in response to changes in activity, suggesting long-term plasticity.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0896-6273(91)90335-wDOIArticle
ORCID:
AuthorORCID
Dickinson, Michael H.0000-0002-8587-9936
Additional Information:© 1991 Cell Press. Received June 6, 1991; revised August 1, 1991. We wish to thank Dr. R. Jahn (Munich, Federal Republic of Germany) for the antibody to p38 and Dr. J. Oberdick for the antibody to L7. We are also grateful to M. Smeyne for her expert help with cell cultures and calcium imaging. K. S. is supported by a research fellowship from the Deutsche Forschungsgemeinschaft (Schi 271/2-2). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC Section 1734 solely to indicate this fact.
Funders:
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)Schi 271/2-2
Issue or Number:6
Record Number:CaltechAUTHORS:20181115-155829070
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20181115-155829070
Official Citation:Karl Schilling, Michael H. Dickinson, John A. Connor, James I. Morgan, Electrical activity in cerebellar cultures determines Purkinje cell dendritic growth patterns, Neuron, Volume 7, Issue 6, 1991, Pages 891-902, ISSN 0896-6273, https://doi.org/10.1016/0896-6273(91)90335-W. (http://www.sciencedirect.com/science/article/pii/089662739190335W)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:90936
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 Nov 2018 00:10
Last Modified:03 Oct 2019 20:30

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