Schilling, Karl and Dickinson, Michael H. and Connor, John A. and Morgan, James I. (1991) Electrical activity in cerebellar cultures determines Purkinje cell dendritic growth patterns. Neuron, 7 (6). pp. 891-902. ISSN 0896-6273. doi:10.1016/0896-6273(91)90335-w. https://resolver.caltech.edu/CaltechAUTHORS:20181115-155829070
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Abstract
In primary dissociated cultures of mouse cerebellum a number of Purkinje cell-specific marker proteins and characteristic ionic currents appear at the appropriate developmental time. During the first week after plating, Purkinje cell dendrites elongate, but as electrical activity emerges the dendrites stop growing and branch. If endogenous electrical activity is inhibited by chronic tetrodotoxin or high magnesium treatment, dendrites continue to elongate, as if they were still immature. At the time that branching begins, intracellular calcium levels become sensitive to tetrodotoxin, suggesting that this cation may be involved in dendrite growth. Even apparently mature Purkinje cells alter their dendritic growth in response to changes in activity, suggesting long-term plasticity.
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Additional Information: | © 1991 Cell Press. Received June 6, 1991; revised August 1, 1991. We wish to thank Dr. R. Jahn (Munich, Federal Republic of Germany) for the antibody to p38 and Dr. J. Oberdick for the antibody to L7. We are also grateful to M. Smeyne for her expert help with cell cultures and calcium imaging. K. S. is supported by a research fellowship from the Deutsche Forschungsgemeinschaft (Schi 271/2-2). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC Section 1734 solely to indicate this fact. | ||||||
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Issue or Number: | 6 | ||||||
DOI: | 10.1016/0896-6273(91)90335-w | ||||||
Record Number: | CaltechAUTHORS:20181115-155829070 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20181115-155829070 | ||||||
Official Citation: | Karl Schilling, Michael H. Dickinson, John A. Connor, James I. Morgan, Electrical activity in cerebellar cultures determines Purkinje cell dendritic growth patterns, Neuron, Volume 7, Issue 6, 1991, Pages 891-902, ISSN 0896-6273, https://doi.org/10.1016/0896-6273(91)90335-W. (http://www.sciencedirect.com/science/article/pii/089662739190335W) | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 90936 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | Tony Diaz | ||||||
Deposited On: | 16 Nov 2018 00:10 | ||||||
Last Modified: | 16 Nov 2021 03:36 |
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